Thanks Beth,
I think these TKIs are so new that they do not fully know all the side effects,
and especially not the long term ones. We are confident in his doctor and he
is watching it closely. Have you reached "undetectable" on your low dose of
tasigna?
Thanks for your good thoughts.
Joyce in IL
On Jul 24, 2015, at 10:36 PM, bkbarney via CMLHope wrote:
> Hi Joyce, I am so glad that your husband's CML numbers are going in the right
> direction. The cml journey is often a balancing act, between the right dosage
> and side effects...Maybe your husband could be on 150 of busutinif with
> time??? It seems that 200 put him close to remission. I had to go off tasigna
> because of elevated liver enzymes, 10 X normal. Going off the med for a short
> time to give the liver a rest, and then using the lowest possible successful
> dosage...seems to work for some people. I hope your husband's liver calms
> down. I will keep my fingers crossed. 18's Beth
>
> -----Original Message-----
> From: Joyce Mesnarich <joy...@htc.net>
> To: cmlhope <cmlhope@googlegroups.com>
> Sent: Fri, Jul 24, 2015 7:50 pm
> Subject: Re: [CMLHope] New results
>
> Jeanie,
> I know you have been dealing with that pain for a long time. Medicine has
> come so far and yet the Good Lord holds some secrets from us. I hope in Sept
> they will get a clue as to the pain's cause.
> Joyce in IL
>
>
> On Jul 24, 2015, at 11:20 AM, 'Icandoallttc' via CMLHope wrote:
>
> Just wanted to say that I take OTC pain killers and have tried prescription
> ones. I have a right side pain that won't go away and they can't find out
> what it is. Nothing seems to help the pain.
> They are doing a ct scan in Sept to see if they can find it but they have
> already done that with no luck. Blessings
>
> My Motto: Faith and Pills
> Jeanie \uD83D\uDC1F\uD83D\uDC1F18,s
> Dx 1/2004. CML Leukemia
> Started Gleevec 2/2004
> Started Tasigna 9/2009
> Started Sprycel 11/2009
> Started Ponatinib January 2015
> Dr Balducci Moffitt Cancer Center
>
> On Jul 24, 2015, at 12:14 PM, "'Icandoallttc' via CMLHope" <
> cmlhope@googlegroups.com> wrote:
>
> Hi Joyce.
> It looks like your liver counts are 1-10% common to increase on that drug.
> Read the information that comes with the meds. Read the whole document
> through.
> They will stabilize as well as other side effects.
> It seems I will go from one side effect to another as time passes.
> Fight on. Good luck.
>
> My Motto: Faith and Pills
> Jeanie \uD83D\uDC1F\uD83D\uDC1F18,s
> Dx 1/2004. CML Leukemia
> Started Gleevec 2/2004
> Started Tasigna 9/2009
> Started Sprycel 11/2009
> Started Ponatinib January 2015
> Dr Balducci Moffitt Cancer Center
>
> On Jul 23, 2015, at 11:43 PM, Joyce Mesnarich < joy...@htc.net> wrote:
>
> Jeanie,
> Thanks for your interest and suggestion. We have gone over all his other
> meds with doctors and nothing should affect the liver. He doesn't take any
> OVC pain meds, or any pain meds. And he does not drink alcohol. The primary
> doctor says that the drug information for bosulif says it can cause liver
> problems, but Dr Talpaz is less certain of that and he is the specialist. He
> says he is watching it closely and I guess we will just trust him. Wayne is
> getting blood tests every other week locally and they are sent to Dr Talpaz.
> The liver enzyme levels seem to have stabilized, although they are elevated.
> As you say, faith and pills. One of Wayne's mottos is "Better living through
> chemistry". LOL I think that used to be part of a TV ad for a large
> chemical company, maybe Du Pont or Monsanto.
>
> Joyce in IL
>
>
> On Jul 23, 2015, at 11:32 AM, 'Icandoallttc' via CMLHope wrote:
>
> Be careful with his diet. Ovc pain pills hurt the liver as well as other
> drugs we take. Ask your pharmacy if any other drugs he take are hurting his
> liver. It's hard but maybe they can figure out something.
> Good luck.
>
> My Motto: Faith and Pills
> Jeanie \uD83D\uDC1F\uD83D\uDC1F18,s
> Dx 1/2004. CML Leukemia
> Started Gleevec 2/2004
> Started Tasigna 9/2009
> Started Sprycel 11/2009
> Started Ponatinib January 2015
> Dr Balducci Moffitt Cancer Center
>
> On Jul 22, 2015, at 2:01 PM, lrc lrc < kneesrb...@gmail.com> wrote:
>
> Joyce does he drink alcohol?
> On Jul 22, 2015 1:43 PM, "margood18 via CMLHope" < cmlhope@googlegroups.com>
> wrote:
> Joyce, so glad to hear that your husband's PCR is lower and I hope that his
> liver function will steady. Best wishes to both of you.
>
> Marcie
>
>
> -----Original Message-----
> From: Joyce Mesnarich < joy...@htc.net>
> To: cmlhope < cmlhope@googlegroups.com>
> Sent: Wed, Jul 22, 2015 12:16 pm
> Subject: [CMLHope] New results
>
> Hello everyone. I have not had time to contribute for awhile. But I must let
> you all know the results of my husband's PCR at his last visit to Dr Talpaz.
> He
> was taken off Sprycel due to pleural effusion and we were hoping his
> undetectable would hold....but it did not. He was subsequently put on bosulif
> and not showing much improvement after 3 months. So his dosage was changed
> from
> 100 mg to 200 mg. And now, after 3 more months, his PCR went from 8.7 to
> 0.127!! Hopefully in another 3 months he will once again reach
> undetectable.
>
> The downside of his test results is that the liver function
> tests have increased a lot. The doctor will not really say that bosulif is to
> blame, but nothing else has changed. Has anyone of you CML warriors had any
> problems with the liver while on TKI's? Was there any treatment to help the
> liver?
>
> God bless you all.
>
> Joyce in IL
>
>
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