People a typically unaware that their machine is infected - because it continues to function perfectly.
That is very true.
We infected a computer in our virus lab with Sobig.F, and you couldn't tell anything unusual was happening. The file didn't seem to do anything when it was run (so the recipient probably figures that the attachment didn't get downloaded or something like that, and probably won't even say "Yes, I ran the program" when asked by an admin), and the only noticeable differences on the system were a couple extra registry entries and system files (files in the \Winnt directory and \Winnt\system32 directory), and a program running in Task Manager (something like "winsst32.exe" that doesn't look unusual).
People who are infected probably would have a somewhat slower Internet connection, but that's probably about all they would notice.
-Scott
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