>
> But N/4 reads will likely contain all the things that diginorms would weed
> out, right ?
> Does diginorm works with read paths in the de Bruijn stored in its Bloom
> filter ?
> If not, not only diginorm does not use pairs, but it does not use read
> threading neither.
>
It does nothing that complicated. Just looks at kmer frequencies and throws
out reads that have k-mers we've already seen enough times. But it's
one-pass, fast, memory efficient algorithm. Not good for GENOME de novo
assembly at the moment, but very useful for de novo RNA-Seq as it flattens
the coverages of transcripts.
--
--Torsten Seemann
--Victorian Bioinformatics Consortium, Dept. Microbiology, Monash
University, AUSTRALIA
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