Rich Ulrich wrote:

> Quite often, as with the HRT, there is the additional problem
> of non-randomization.  For that, I also consider the effect size,
> too, and say, "Can I imagine particular  biases that could
> cause this result?"  

With HRT, there is a further problem.  The early epidemiological studies
showing benefit all involved estrogen alone.  The recent studies involve
estrogen plus progestin.
.
.
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