> On 4 Oct 2020, at 20:56, Philip Thrift <[email protected]> wrote: > > > pdf: > https://www.bakerlab.org/wp-content/uploads/2020/08/Lajoie-coLOCKR2020.pdf
Thanks. This confirms somehow what I said. Impressive work. No doubt about that. Bruno > > > via > Baker Lab, Institute for Protein Design > University of Washington, Seattle. > https://www.bakerlab.org/ > > > > > On Sunday, October 4, 2020 at 11:03:14 AM UTC-5 Lawrence Crowell wrote: > It makes sense. The phosphorylation of a protein changes its shape. We can > think of these different conformal shapes as different logical conditions or > states. > > LC > > On Sunday, October 4, 2020 at 7:07:49 AM UTC-5 [email protected] > <applewebdata://C8D10DC6-3684-4ED2-8E2F-7FE9CF92D243> wrote: > In the September 25 2020 issue of the journal Science researchers report on > the invention of a sequence of switches made entirely of protein that can > perform AND OR and NOT Boolean logical operations, and thus is Turing > Complete, they call it Co-LOCKR. And they were able to put this simple > computer into a T-Cell antibody, and so they could activate the T-Cell only > when specific conditions are met. > > Designed protein logic to target cells with precise combinations of surface > antigens <https://science.sciencemag.org/content/369/6511/1637> > > By examining the antigens on the surface of a specific type of cancer cell > you can distinguish cancer cells from healthy normal cells, but it's more > complex than just looking for one specific antigen. However with Co-LOCKR a > T-Cell could be programmed for example, to only attack cells that have > antigens W OR X AND NOT both on their surface, AND antigen Y, AND NOT > antigen Z. That way the T cell would attack cancerous cells but leave normal > healthy cells alone. This is almost starting to sound a little like a > simplified version of one of Drexler's Nanomachines. > > John K Clark > > -- > You received this message because you are subscribed to the Google Groups > "Everything List" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected] > <mailto:[email protected]>. > To view this discussion on the web visit > https://groups.google.com/d/msgid/everything-list/8bfc52b3-520d-4602-ad85-54c5af691976n%40googlegroups.com > > <https://groups.google.com/d/msgid/everything-list/8bfc52b3-520d-4602-ad85-54c5af691976n%40googlegroups.com?utm_medium=email&utm_source=footer>. -- You received this message because you are subscribed to the Google Groups "Everything List" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. To view this discussion on the web visit https://groups.google.com/d/msgid/everything-list/69405439-4890-4D2E-BDD2-BDB212F1D401%40ulb.ac.be.
