pdf: https://www.bakerlab.org/wp-content/uploads/2020/08/Lajoie-coLOCKR2020.pdf
via Baker Lab, Institute for Protein Design University of Washington, Seattle. https://www.bakerlab.org/ On Sunday, October 4, 2020 at 11:03:14 AM UTC-5 Lawrence Crowell wrote: > It makes sense. The phosphorylation of a protein changes its shape. We can > think of these different conformal shapes as different logical conditions > or states. > > LC > > On Sunday, October 4, 2020 at 7:07:49 AM UTC-5 [email protected] wrote: > >> In the September 25 2020 issue of the journal Science researchers report >> on the invention of a sequence of switches made entirely of protein that >> can perform AND OR and NOT Boolean logical operations, and thus is Turing >> Complete, they call it Co-LOCKR. And they were able to put this simple >> computer into a T-Cell antibody, and so they could activate the T-Cell >> only when specific conditions are met. >> >> Designed protein logic to target cells with precise combinations of >> surface antigens <https://science.sciencemag.org/content/369/6511/1637> >> >> By examining the antigens on the surface of a specific type of cancer >> cell you can distinguish cancer cells from healthy normal cells, but >> it's more complex than just looking for one specific antigen. However with >> Co-LOCKR a T-Cell could be programmed for example, to only attack cells >> that have antigens W OR X AND NOT both on their surface, AND antigen Y, >> AND NOT antigen Z. That way the T cell would attack cancerous cells but >> leave normal healthy cells alone. This is almost starting to sound a little >> like a simplified version of one of Drexler's Nanomachines. >> >> John K Clark >> > -- You received this message because you are subscribed to the Google Groups "Everything List" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. To view this discussion on the web visit https://groups.google.com/d/msgid/everything-list/8bfc52b3-520d-4602-ad85-54c5af691976n%40googlegroups.com.
