Found some more info on VO ya'll might be
interested in.
From Virbac's FAQ: http://www.virbagenomega.com/uk/faqcat
Q: After reconstitution of Virbagen®
Omega, can the vial be stored overnight and used on an animal the next
day?
A: Studies have demonstrated a stability
of the molecule up to 3 weeks minimum at +4°C. Nevertheless, taking
into consideration the fact that there is no preservative in the
formulation of the product, the risk of contamination with fungus or
bacteria exists. Nevertheless, if injections are performed in asepsis
conditions (sterile needles...), the risk of contamination will be
minimum.
Q: Can Virbagen® Omega be frozen after
reconstitution?
A: Feline omega interferon is a
glycoprotein which is very stable in general. After resuspension,
stability studies showed that the solution was stable for at least 3
weeks at +4°C. According to knowledge on the molecule, it does not seem
there is any risk linked to freezing the solution. Nevertheless,
precise data concerning this type of storage are not available to date.
In any case, several cycles of freezing-thawing are not recommended.
The official pdf documents filed with the
European Medicines Agency are here: http://www.emea.eu.int/vetdocs/vets/Epar/virbagenomega/virbagenomega.htm
The "Scientific Discussion" is real
detailed and informative.
The "Product Information" looks like the
official Product Insert info.
Australian FDA info: http://www.apvma.gov.au/gazette/gazette0111p14.shtml
A study where only 1 round of 5 injections
was applied for FeLV, instead of the recommended 3 rounds: http://vetinterferon.nexenservices.com/aff_abstract.php?id=55&lang=eng
I was interested in possible interference
with Immunoregulin and/or continuing with Immunoregulin after VO
therapy is complete. The Scientific Discussion has a small blurb that
says "Due to the indications for use, concomitant use of immunological
products is not recommended." Yet interestingly, the Product
Information is silent on this. So I emailed Virbac and they said:
"Unfortunately, as far as I am aware,
ImmunoRegulin is not available in Europe and we do not have any data on
the use of it either concurrently with Virbagen Omega or before/after
VO treatment. There are products available in Europe (Baypamun HK and
Acemannan) that are similar in concept to ImmunoRegulin. My
understanding of these products is that they work by inducing the
production of endogenous cytokines (including Interferons) but that
placebo controlled studies have failed to demonstrate a significant
benefit of treatment with these products. On this basis I can see
little benefit in continuing with ImmunoRegulin treatment as Virbagen
Omega effectively bypasses the need to produce endogenous type 1
interferons and will stimulate an immunological cascade itself."
Anyone know what that means?
-Kyle
