Thanks very much for the article. This is consistent with what I've heard, mostly in years past on this list, possibly from Tally (www.tallyville.com/interferon.html) . It is Low Dose Oral Interferon alpha, as I understand drastically different from high dose injected interferon given to humans for cancer treatment.

The other protocols I've seen listed are 3 days on/3 off, and 7 days on/7 off. I've seen folks express concern that cats will become "immune" to the interferon, if they're not off it for a while. One justification for daily use is that FELV cats don't have enough naturally occurring Interferon to support their immune systems. Now that's just a theory I've seen posted on this list, from years back.

Gloria





On Sep 30, 2009, at 2:10 AM, Alice Flowers wrote:

Here are some excerpts from some research on Interferon-I have been giving it 2x a day-orally 1 cc to Rosie and Murphy. I had been giving it onece a day to the other 4 that passed away. I always give it right before the canned food-they both come into the kitchen and pester me, Murphy bangs the cabinet door until I get the little syringe filled. Then they sit and wait for the little squirt, Rosie will tilt her head sideways-she likes it squirted on the right side of her mouth, I don't have to force them to take it, it's just the routine. I even tasted it, just tastes like saline solutine-similar to sinus rinse or saline nasal spray. I have not noticed any side effects, except maybe lately, combined with the Imulan treatments the last 2 weeks-they are playing much more and are awake for longer periods and are looking for things to get into. They are making up for being so sick the first year.

WHY IS DAILY DOSING BETTER?
Jere Hough
Three Times Weekly Is A Terribly Poor Way to Dose Interferon....
This is a great article and also discusses the development of longer acting pegylated interferons to better manage the peak and valley effects of the current generation of Interferons: “PEAKS AND VALLEYS - Because interferon has a half-life in serum of only about 7 -10 hours. This means it peaks in the body at about 12 hours and is then rapidly metabolized and excreted. At 24 hours after injection it is barely measurable. By 36 hours it is not detectable with current measurements. During this peak the is a rapid, dramatic drop in viral load. As the levels of interferons quickly drop to negligible levels at about 24 hours viral loads start rapidly climbing again. By 48 or especially 72 hours much of the gain in viral reduction has been lost. In other words, viral loads in the body fluctuate directly and rapidly along with levels of interferon in serum, and when plotted on a graph look like a sine wave, or a roller coaster. This graph, along with a description of this phenomena, can be viewed on many websites and texts on the subject, including the http://www.roche-hepc.com/ page. These peaks and valleys have been followed for days in human subjects, and are invariably similar in those who respond to IFN. As interferon levels go up viral loads go down immediately. Then as IFN levels drop, viral loads increase again rapidly. In the period from 24 to 48 hours viral loads peak to erase most of the gains made. In standard TIW dosing the increase in viral loads is even more pronounced during the 72 hour break once each week.” 1) NEVER give with food. Inteferon breaks down in the stomach with stomach acid. Always squirt it directly into the mouth where it is absorbed in the mouth and throat lining. #2) ALWAYS keep refridgerated. It's useless if it hits room temperature. Keep unused dilutions frozen until needed. It's unknown how long Interferon stays effective in the fridge. Keep unused dilutions frozen until needed. #3) It's USELESS to do on/off dosing. It MUST be given every 24 hours to maintain consistent levels in the bloodstream. (See excerpts below regarding peaks and valleys). It must be kept in the blood at all times. On/Off protocols are worthless because it progresses forward in times of no intervention.

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