Thanks very much for the article. This is consistent with what I've
heard, mostly in years past on this list, possibly from Tally (www.tallyville.com/interferon.html)
. It is Low Dose Oral Interferon alpha, as I understand drastically
different from high dose injected interferon given to humans for
cancer treatment.
The other protocols I've seen listed are 3 days on/3 off, and 7 days
on/7 off. I've seen folks express concern that cats will become
"immune" to the interferon, if they're not off it for a while. One
justification for daily use is that FELV cats don't have enough
naturally occurring Interferon to support their immune systems. Now
that's just a theory I've seen posted on this list, from years back.
Gloria
On Sep 30, 2009, at 2:10 AM, Alice Flowers wrote:
Here are some excerpts from some research on Interferon-I have been
giving it 2x a day-orally 1 cc to Rosie and Murphy. I had been
giving it onece a day to the other 4 that passed away. I always give
it right before the canned food-they both come into the kitchen and
pester me, Murphy bangs the cabinet door until I get the little
syringe filled. Then they sit and wait for the little squirt, Rosie
will tilt her head sideways-she likes it squirted on the right side
of her mouth, I don't have to force them to take it, it's just the
routine. I even tasted it, just tastes like saline solutine-similar
to sinus rinse or saline nasal spray. I have not noticed any side
effects, except maybe lately, combined with the Imulan treatments
the last 2 weeks-they are playing much more and are awake for longer
periods and are looking for things to get into. They are making up
for being so sick the first year.
WHY IS DAILY DOSING BETTER?
Jere Hough
Three Times Weekly Is A Terribly Poor Way to Dose Interferon....
This is a great article and also discusses the development of longer
acting pegylated interferons to better manage the peak and valley
effects of the current generation of Interferons:
“PEAKS AND VALLEYS - Because interferon has a half-life in serum of
only about 7 -10 hours. This means it peaks in the body at about 12
hours and is then rapidly metabolized and excreted. At 24 hours
after injection it is barely measurable. By 36 hours it is not
detectable with current measurements. During this peak the is a
rapid, dramatic drop in viral load. As the levels of interferons
quickly drop to negligible levels at about 24 hours viral loads
start rapidly climbing again. By 48 or especially 72 hours much of
the gain in viral reduction has been lost.
In other words, viral loads in the body fluctuate directly and
rapidly along with levels of interferon in serum, and when plotted
on a graph look like a sine wave, or a roller coaster. This graph,
along with a description of this phenomena, can be viewed on many
websites and texts on the subject, including the http://www.roche-hepc.com/
page. These peaks and valleys have been followed for days in human
subjects, and are invariably similar in those who respond to IFN.
As interferon levels go up viral loads go down immediately. Then as
IFN levels drop, viral loads increase again rapidly. In the period
from 24 to 48 hours viral loads peak to erase most of the gains
made. In standard TIW dosing the increase in viral loads is even
more pronounced during the 72 hour break once each week.”
1) NEVER give with food. Inteferon breaks down in the stomach with
stomach acid. Always squirt it directly into the mouth where it is
absorbed in the mouth and throat lining.
#2) ALWAYS keep refridgerated. It's useless if it hits room
temperature. Keep unused dilutions frozen until needed. It's unknown
how long Interferon stays effective in the fridge. Keep unused
dilutions frozen until needed.
#3) It's USELESS to do on/off dosing. It MUST be given every 24
hours to maintain consistent levels in the bloodstream. (See
excerpts below regarding peaks and valleys). It must be kept in the
blood at all times. On/Off protocols are worthless because it
progresses forward in times of no intervention.
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