Here are some excerpts from some research on Interferon-I have been giving it 
2x a day-orally 1 cc to Rosie and Murphy. I had been giving it onece a day to 
the other 4 that passed away. I always give it right before the canned 
food-they both come into the kitchen and pester me, Murphy bangs the cabinet 
door until I get the little syringe filled. Then they sit and wait for the 
little squirt, Rosie will tilt her head sideways-she likes it squirted on the 
right side of her mouth, I don't have to force them to take it, it's just the 
routine. I even tasted it, just tastes like saline solutine-similar to sinus 
rinse or saline nasal spray. I have not noticed any side effects, except maybe 
lately, combined with the Imulan treatments the last 2 weeks-they are playing 
much more and are awake for longer periods and are looking for things to get 
into. They are making up for being so sick the first year.
 
WHY IS DAILY DOSING BETTER?
Jere Hough
Three Times Weekly Is A Terribly Poor Way to Dose Interferon.... 
This is a great article and also discusses the development of longer acting 
pegylated interferons to better manage the peak and valley effects of the 
current generation of Interferons: 
“PEAKS AND VALLEYS - Because interferon has a half-life in serum of only about 
7 -10 hours. This means it peaks in the body at about 12 hours and is then 
rapidly metabolized and excreted. At 24 hours after injection it is barely 
measurable. By 36 hours it is not detectable with current measurements. During 
this peak the is a rapid, dramatic drop in viral load. As the levels of 
interferons quickly drop to negligible levels at about 24 hours viral loads 
start rapidly climbing again. By 48 or especially 72 hours much of the gain in 
viral reduction has been lost. 
In other words, viral loads in the body fluctuate directly and rapidly along 
with levels of interferon in serum, and when plotted on a graph look like a 
sine wave, or a roller coaster. This graph, along with a description of this 
phenomena, can be viewed on many websites and texts on the subject, including 
the http://www.roche-hepc.com/ page. These peaks and valleys have been followed 
for days in human subjects, and are invariably similar in those who respond to 
IFN. 
As interferon levels go up viral loads go down immediately. Then as IFN levels 
drop, viral loads increase again rapidly. In the period from 24 to 48 hours 
viral loads peak to erase most of the gains made. In standard TIW dosing the 
increase in viral loads is even more pronounced during the 72 hour break once 
each week.” 
1) NEVER give with food. Inteferon breaks down in the stomach with stomach 
acid. Always squirt it directly into the mouth where it is absorbed in the 
mouth and throat lining. 
#2) ALWAYS keep refridgerated. It's useless if it hits room temperature. Keep 
unused dilutions frozen until needed. It's unknown how long Interferon stays 
effective in the fridge. Keep unused dilutions frozen until needed. 
#3) It's USELESS to do on/off dosing. It MUST be given every 24 hours to 
maintain consistent levels in the bloodstream. (See excerpts below regarding 
peaks and valleys). It must be kept in the blood at all times. On/Off protocols 
are worthless because it progresses forward in times of no intervention. 
 
_______________________________________________
Felvtalk mailing list
[email protected]
http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org

Reply via email to