Thanks so far for the suggestions everyone. 

I tried using the SlicerMorph extension of 3D Slicer v. 5.3.0, but every 
time I run it the program crashes. The DICOM file is about 2 GB, and I'm on 
a powerful workstation that I regularly use for CT data segmention in 
VGStudio Max. Has anyone else had this problem or know a workaround? I'm 
trying to generate a cranial endocast of a gray seal skull, to give you an 
idea of size. The cranium is about 16 cm long and 10 cm wide at its max, 
and the scan resolution is about 0.11 mm.

I looked into the Arothron package but notice it only runs on meshes, is 
that correct? Because the seal skull is so thin at places, the meshes are 
rather hole-y. That's why I figured there might be a benefit of working in 
the CT data, but maybe I'm wrong.

I'm open to more suggestions and thanks again for any feedback!

Christy

On Thursday, February 23, 2023 at 2:12:05 PM UTC+1 Thomas O'Mahoney wrote:

> Dear Christy, 
> 2 freeware options:
> You can do this in 3Dslicer using the extension Slicermorph's 'segment 
> endocranium' function (Slicer can obviously segment the original stacks 
> from a wide variety of sanners as well): 
> https://github.com/SlicerMorph/SlicerMorph#module-descriptions
> If you already have 3d models from segmentation, you can use the Endomaker 
> function in the R package Arothron. This is particularly useful if you have 
> lots of models and want to easily fully automate this via scripting. 
> https://doi.org/10.1002/ajpa.24043 
> Both Murat Maga (PI on Slicermorph) and Antonio Profico  (who wrote 
> Endomaker) are members of this list. 
> Regards, 
> Tom
>
>
>
> On Thu, 23 Feb 2023 at 11:43, Christy Hipsley <[email protected]> 
> wrote:
>
>> Hi all,
>>
>> I'm looking for programs to generate cranial endocasts from CT data of 
>> mammal skulls. While I can do this manually, I prefer something 
>> (semi-)automated to minimise potential user-bias. 
>>
>> Thanks for any advice,
>> Christy
>>
>> *Dr Christy Anna Hipsley | **Associate Professor*
>> Department of Biology, University of Copenhagen
>>
>>
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