Paul,
ITK-Snap is a nice tool, but I am surprised you couldn't do what you wanted 
to do in 3D Slicer as it is quite feature rich. As a comprehensive program, 
Slicer does have a longer (but not necessarily any steeper) curve than 
ITK-Snap. Our goal in SlicerMorph is to ease that curve. Here are couple 
documentation on segmentation in Slicer, if you would like to give another 
try:

*Endocast segmentation tutorial *written by a student on forum: 
https://slicermorph.github.io/Endocast_creation.html. It explains two 
different approach to manually segment endocrania, and then compares their 
output to Segment Endocranium modules one  (this is a few years old, so 
menus look a little different than current version, but the functionality 
is identical). 

*And our segmentation tutorials*: 
https://github.com/SlicerMorph/Tutorials/tree/main/Segmentation

The nice thing about ITK-Snap it uses the same open-source libraries as 
Slicer (namely ITK) so whatever you do in it, you can bring it Slicer (or 
vice versa). 

On Thursday, February 23, 2023 at 12:38:59 PM UTC-8 Paul Penkalski wrote:

> Hi Christy,
> Another good option is ITK-SNAP: http://www.itksnap.org/
>
> Although it isn't designed specifically to segment endocraniums, it
> has several automatic algorithms that I've used to segment fossil
> braincases automatically and it worked really well. You may have to
> clean up the segmentation a little at the end, but that's true for any
> program. Then you can save the segmentation as a 3D model or mesh.
>
> You might download it and do a quick test segmentation, and you'll see
> how straighforward it is. I had tried 3D Slicer prior to that and
> couldn't get it to do anything useful. Then someone recommended
> ITK-SNAP. Of course there are a few commercial apps too, but they
> aren't any easier to use, and not really any more powerful than ITK,
> and obviously more expensive.
>
> Downsampling the scan is a good idea. I often do that. You can also
> crop it, e.g. if it's a scan of the whole skull and you only need to
> segment the endocranium. I like IrfanView which can do batch crop and
> resize and has a DICOM plugin (and it's free, at least the older
> versions). 0.1 mm is pretty high resolution unless you're scanning
> mice!
>
> Cheers,
> Paul P.
>
>
> On 2/23/23, Murat Maga <[email protected]> wrote:
> > Without the data it is hard to tell, but often those crashes are memory
> > related. Memory usage during segmentation increases 8-10 folds based on 
> the
> > segmentation effect being used. So if your dataset is 2GB, you need 
> minimum
> > of 16-20GB of "available" RAM for Slicer to work properly. If you can 
> share
> > your dataset, I can take a look.
> >
> > Also for endocast segmentation there is no need to work with full
> > resolution images. You can downsample your image (via the CropVolume) by 
> 2,
> > and then try. That will reduce your data volume by 8 folds. Your
> > experiments will go faster too.
> >
> > The other important parameters is the size of the largest hole to plug, 
> and
> > the smoothing. Default parameters we included worked fine for large apes,
> > but I am not sure for seal skulls.
> >
> >
> >
> > On Thursday, February 23, 2023 at 7:24:30 AM UTC-8 Christy Hipsley wrote:
>

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