That's the driver topology I use, except I omit the zener diode (good idea, 
though, for NMOS) and the base resistor because I dont see a hazard without 
them. If there is a power-on transient that occurs when the HV supply is 
energized (very unlikely, because the HV DC filter cap would need to be 
missing/open) , it would be a positive voltage-spike and the worst it could 
do is cause the driver NPN to turn-on briefly. More-likely, any leakage 
from collector-to-base would bleed-away thru the ESD network on the driving 
logic; the charge would be very small, perhaps negligible, because it would 
be whatever leaked from the collector of the driver NPN to the base (this 
is a reverse-biased junction). Regardless, there still is current-limiting 
because of the emitter resistor.

I'm not aware of any mechanism that would cause a current-spike thru the 
tube at turn-on. When the logic goes to '1', the transistor will turn on 
rapidly, and it may actually saturate because the tube itself requires 
several microseconds to ionize. During this time the base-current will be 
at it's maximum (the target tube current). As the tube ionizes, it's 
current will go thru the transistor and the negative feedback at the 
emitter will gradually reduce the base-current from the logic. There's 
definitely a current-spike from the driving logic as the tube stabilizes, 
but it's only a few mA. You could add a series base-resistor to reduce the 
peak base-current, but if you check the datasheet for the transistor it's 
very likely the max base-current spec is much higher, making the resistor 
unnecessary. Unless I'm really missing something, I dont see where current 
thru the tube will spike at turnon or turnoff.

As far as a current-spike at tube turnon/turnoff, yes there will be some 
Ldi/dt and 1/2LI^2 effects, but they will be small because we're dealing 
with milliamps. For example, if you are switching 5mA off in 10nsec, and 
there is 1uH of wiring inductance, the voltage spike (Ldi/dt) is 0.5 volts. 
[ Imagine if this was a motor controller with a 50 amp load.....ouch!... 
but there are circuit techniques to deal with that ].

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