I quick-glanced the HV5812 datasheet, and it's a push-pull driver, meaning 
that it drives-out approx 0 volts to turn the tube on, and 80V to turn the 
tube off. Even though the anode supply is significantly higher than the 80V 
rating of the HV5812 device, it's OK to do this because any leakage thru 
the nixie tube is clamped to around 80V by the ESD circuitry in the HV5812. 
As long as the tube's extinguishing voltage is greater  than 
(Anode_supply_voltage - Driver_high_voltage), this clever driver trick will 
work nicely.

This is not the same situation with open-drain (aka open-collector) 
outputs, which have no clamps for positive voltage. Theoretically a tube 
could 'leak' a small current and drive the pin above it's rated limit. Not 
usually a problem for bipolar devices, but it will destroy a MOS device, 
which is why I dont recommend exceeding the datasheet parameters.

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