My MAX1771 design can probably be pushed to that. Yes, C4 & C6 would have 
to be higher voltage and R2 changed - the PRC221 range have a working 
voltage of 200V but are safe to 500V - it would be better to find a 2512 
footprint resistor with a 300 or 350 volt working for long term reliability.

D1 would need to be changed from an ES2F to an ES2G (same footprint, 400V 
Vrrm) but it may be better to find one with the same footprint (SMB) which 
has a higher RMS working voltage.

A lower ESR FET would also be a good plan - see the web page for details - 
https://nick.desmith.net/Electronics/NixiePSU.html 

Nick

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