I would suggest you create an app for the problem application(s) and make them 
server-specific.  Then you can at least determine if the issue is with one or 
both of your servers.  
 
This is Win 2008 R2?  Office 2010 64 or 32?  If Office, try a down version or 
32 instead of 64, at least for testing.  
 
I had a similar issue.  In one case the app had to be removed/re-installed on 
the XenApp server, on the other it was printer drivers (we use session 
printing).  I think the event logs told me something was wrong for the first 
instance.  
 
the other thing I can think of is to check how you have your profiles 
configured.  We use terminal server roaming profiles.  Works okay except for 
occasionally when a user does something to fill up the allocated space.
 
Tom

>>> Sohail Qadir <[email protected]> 5/26/2011 11:33 AM >>>
Hi Guys,
I have an issue at one of my client site. We upgraded from 4.5 to xenapp 5.0 
farm with 2 xenapp servers running on VM with about 100 users. Both Vm has 4 GB 
ram each and have enough space.
Some of the users are having an issue where their session freezes when they are 
running office applications such as outlook, word and they cant do anything at 
that point except a hard shutdown. Also they are not able to reconnect to their 
sessions either. 
In the managment console, the session shows active and the user are not able to 
reload the application untill the Admin resets the active connection from the 
management console.
So far we have troubleshooted the user side, we know that its not their 
connections, We have also created a new farm on a pyhsical server with the old 
secure gateway and the issue still exists. We also went ahead a patched both 
servers and the issue still exists.
Any help would be greatly appreciated.
Thanks
Sohail Qadir

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