I seem to recall something a while back where this would happen if
apache lost its connection to mysql.  Are you getting any "mysql server
has gone away" style messages in syslog?

John Wells wrote:
>
> Don't know if it's related, but around the same time it stops
> replying, incoming email users also get:
>
> Subject: Message not recorded
>
> Permission Denied
>
> When trying to reply...
>
> Nothing of interest in the logs at all as far as I can tell. Messages
> look usual. I've put the entire log here:
> http://www.timco.aero/rt.messages momentarily for perusal.
>
> We'll pay for help resolving this if it's necessary (and reasonable ;) ).
>
> Thanks,
> John
>
>
> -- 
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