Re: [Felvtalk] LTCI etc..Interferon Heidi
We were giving all 6 kittens Interferon once a day 1cc orally. After the 4 brothers passed, we went to 2x a day after reading that it doesn't keep the virus from multiplying the full 24 hours. Plus, our cats have never had a reaction to taking it once a day, they even come in the kitchen and sit when it's time for the little squirt. We are all just scrambling for any hope. I am lucky that our vet really cares for our kitties and supports us in obtaining the LTCI for us and is just a phone call away. Here is the passage from that document on Interferon: -- #1) NEVER give with food. Inteferon breaks down in the stomach with stomach acid. Always squirt it directly into the mouth where it is absorbed in the mouth and throat lining. #2) ALWAYS keep refridgerated. It's useless if it hits room temperature. Keep unused dilutions frozen until needed. It's unknown how long Interferon stays effective in the fridge. Keep unused dilutions frozen until needed. #3) It's USELESS to do on/off dosing. It MUST be given every 24 hours to maintain consistent levels in the bloodstream. (See excerpts below regarding peaks and valleys). It must be kept in the blood at all times. On/Off protocols are worthless because it progresses forward in times of no intervention. It is relatively new, and being used "off-label" which means no studies were done for FDA approval in animals. The use of Interferon for feline viruses was experimental and the results that vets who use it are seeing are being shared and tried by others. Most of the medications used in veterinary practise are "off-label" human medications that have FDA approvals based on human trials and you will not find specific studies done on cats or dogs unless the drug was specifically developed for, and tested in animals for FDA approval. Interferon is Interferon. It acts the same way in cats as it does in humans. The recent understanding that low doses can be as effective as the higher, more toxic doses and a better understanding of diluting and freezing the Interferon to extend its shelf life has meant great strides in it's use in veterinary medicine. The purpose of low dose Interferon in cats is to mimic the same levels that are naturally produced in response to a viral attack. Many people ask what is the connection between human viral treatments and feline, and why should I care? The connection is this. Viruses all work the same way. They may be species specific, but their biochemical mechanisms are the same. Just as we use human Amoxycillin to treat bacterial infections in both humans and cats, so too can human anti-virals work to help reduce viral loads in cats. Interferon works the same way against the Hepatitis C virus in humans. If you read the La Roche link you will see that the primary functions of Interferon are: anti-viral, anti-proliferative and immunomodulatory. It "interferes" with the virus replication. By keeping the level of the virus down in the host's system it allows the cat's own weakened immune system to help suppress symptoms. The lower dose in veterinary practise is not designed to eradicate the virus as it is with Hepatitis C. Cats chronically infected with FIV or Herpes will always have the virus, so the high dosage therapy is of really no use. The idea is to either replace or supplement the levels of natural Interferon the cat is either not producing or not producing enough of. Interferons are natural virus killers. There are definitely some immune boosting benefits to Interferon but it's primary function is to keep the viral load in the system down. WHY IS DAILY DOSING BETTER? Jere Hough Three Times Weekly Is A Terribly Poor Way to Dose Interferon This is a great article and also discusses the development of longer acting pegylated interferons to better manage the peak and valley effects of the current generation of Interferons: “PEAKS AND VALLEYS - Because interferon has a half-life in serum of only about 7 -10 hours. This means it peaks in the body at about 12 hours and is then rapidly metabolized and excreted. At 24 hours after injection it is barely measurable. By 36 hours it is not detectable with current measurements. During this peak the is a rapid, dramatic drop in viral load. As the levels of interferons quickly drop to negligible levels at about 24 hours viral loads start rapidly climbing again. By 48 or especially 72 hours much of the gain in viral reduction has been lost. In other words, viral loads in the body fluctuate directly and rapidly along with levels of interferon in serum, and when plotted on a graph look like a sine wave, or a roller coaster. This graph, along with a description of this phenomena, can be viewed on many websites and texts on the subject, including the http://www.roche-hepc.com/ page. These peaks and valleys have been followed for days in human subjects, and are invariably similar in those who respond to IFN. As inte
Re: [Felvtalk] LTCI Rumor (for Heidi)
Thank you for the information on the LTC1. What about Interferon?? I rescued a kitten a few weeks ago and he is FelV positive, otherwise healthy and showing no symptoms. I have him isolated in a room away from my other cats and am trying to keep him comfortable. I am trying to find him a home where he can be an only cat and will be kept indoors but I know this will be difficult. I am feeling kind of hopeless as it sounds like many of your sweet cats didn't make it past 1 year. My vet said he could live many years if kept in the right environment but now I am not sure this is true. I appreciate your feedback. I hope I can find a home for Little as he is such a nice boy. If you know of any sites where I can post his pic please et me know as I don't ant to give up yet. Heidi --- On Sat, 8/7/10, Natalie wrote: From: Natalie Subject: Re: [Felvtalk] LTCI Rumor (for Heidi) To: felvtalk@felineleukemia.org Date: Saturday, August 7, 2010, 6:18 PM Wouldn't it help to use PetTinic in food for anemic cats? I use it often, not necessarily for FIV/FeLV positive cats. Natalie -Original Message- From: felvtalk-boun...@felineleukemia.org [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Alice Flowers Sent: Saturday, August 07, 2010 8:09 PM To: felvtalk@felineleukemia.org Subject: Re: [Felvtalk] LTCI Rumor (for Heidi) Heidi-here is a good link that describes the product: http://www.imulan.com/felv-fiv-treatment.html It is from the Imulan Company and it's called LTCI. There has been increased interest in the product for FeLV and FIV cats. I have had 2 cats on it for almost a year. Does it work, I don't know as both of mine are still positive-but I truly believe their health has been improved with this product. We lost Rosie's 4 littermates last year before they reached a year old-Rosie is turning 2 this month!! YAY! The literature said that some cats can fight off the virus and test negative. Rosie is doing great but Murphy has been struggling the past 2-3 weeks with anemia, but is trying hard to rally back. He became so anemic a few weeks ago and I thought we were going to lose him. I think part of it may be due to trying to go 2 months and more between injections. Before that-they were both in the high 30s with HCT, and actually Rosie's last HCT was on 7/24 and it was 46.5. I started the treatments before they became ill, some people begin it when symptoms appear and they find this product out there in web searches. I hope your sweet little baby stays healthy. As you can tell from the postings on this site, many of us have lost our dear fur-children, I don't think it ever gets easier. Alice ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
Re: [Felvtalk] LTCI Rumor (for Heidi)
Wouldn't it help to use PetTinic in food for anemic cats? I use it often, not necessarily for FIV/FeLV positive cats. Natalie -Original Message- From: felvtalk-boun...@felineleukemia.org [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Alice Flowers Sent: Saturday, August 07, 2010 8:09 PM To: felvtalk@felineleukemia.org Subject: Re: [Felvtalk] LTCI Rumor (for Heidi) Heidi-here is a good link that describes the product: http://www.imulan.com/felv-fiv-treatment.html It is from the Imulan Company and it's called LTCI. There has been increased interest in the product for FeLV and FIV cats. I have had 2 cats on it for almost a year. Does it work, I don't know as both of mine are still positive-but I truly believe their health has been improved with this product. We lost Rosie's 4 littermates last year before they reached a year old-Rosie is turning 2 this month!! YAY! The literature said that some cats can fight off the virus and test negative. Rosie is doing great but Murphy has been struggling the past 2-3 weeks with anemia, but is trying hard to rally back. He became so anemic a few weeks ago and I thought we were going to lose him. I think part of it may be due to trying to go 2 months and more between injections. Before that-they were both in the high 30s with HCT, and actually Rosie's last HCT was on 7/24 and it was 46.5. I started the treatments before they became ill, some people begin it when symptoms appear and they find this product out there in web searches. I hope your sweet little baby stays healthy. As you can tell from the postings on this site, many of us have lost our dear fur-children, I don't think it ever gets easier. Alice ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
Re: [Felvtalk] LTCI Rumor (for Heidi)
Heidi-here is a good link that describes the product: http://www.imulan.com/felv-fiv-treatment.html It is from the Imulan Company and it's called LTCI. There has been increased interest in the product for FeLV and FIV cats. I have had 2 cats on it for almost a year. Does it work, I don't know as both of mine are still positive-but I truly believe their health has been improved with this product. We lost Rosie's 4 littermates last year before they reached a year old-Rosie is turning 2 this month!! YAY! The literature said that some cats can fight off the virus and test negative. Rosie is doing great but Murphy has been struggling the past 2-3 weeks with anemia, but is trying hard to rally back. He became so anemic a few weeks ago and I thought we were going to lose him. I think part of it may be due to trying to go 2 months and more between injections. Before that-they were both in the high 30s with HCT, and actually Rosie's last HCT was on 7/24 and it was 46.5. I started the treatments before they became ill, some people begin it when symptoms appear and they find this product out there in web searches. I hope your sweet little baby stays healthy. As you can tell from the postings on this site, many of us have lost our dear fur-children, I don't think it ever gets easier. Alice ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
Re: [Felvtalk] LTCI Rumor
hello, I have a kitten that is FElV positive. Can you tell me what LTCI is? Is this something I should be giving the kitten to help keep healthy? Thanks,Heidi Werber --- On Sat, 8/7/10, Sara Kasteleyn wrote: From: Sara Kasteleyn Subject: Re: [Felvtalk] LTCI Rumor To: felvtalk@felineleukemia.org Date: Saturday, August 7, 2010, 11:16 AM Hi Alice, I've not heard anything about this,and we have used it for our little one. We have one dose left, so are on the verge of asking our vet to re-order. Will pass along what we find. Thanks for the heads-up. Sara --Original Mail-- From: "Alice Flowers" To: "felvtalk@felineleukemia.org" Sent: Sat, 7 Aug 2010 10:18:36 -0700 PDT Subject: [Felvtalk] LTCI Rumor I am hearing that after Sept or so, the new distributors of the LTCI will only sell 10 packs-this is going to make it very difficult for most of us to afford-plus the price went up. I think they are wanting the veterinarians to carry the product in stock-but I am thinking most won't - Like my vet...I researched and found the product and begged them to order it for me. Has anyone else heard anything about this?? ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
Re: [Felvtalk] LTCI Rumor
Hi Alice, I've not heard anything about this,and we have used it for our little one. We have one dose left, so are on the verge of asking our vet to re-order. Will pass along what we find. Thanks for the heads-up. Sara --Original Mail-- From: "Alice Flowers" To: "felvtalk@felineleukemia.org" Sent: Sat, 7 Aug 2010 10:18:36 -0700 PDT Subject: [Felvtalk] LTCI Rumor I am hearing that after Sept or so, the new distributors of the LTCI will only sell 10 packs-this is going to make it very difficult for most of us to afford-plus the price went up. I think they are wanting the veterinarians to carry the product in stock-but I am thinking most won't - Like my vet...I researched and found the product and begged them to order it for me. Has anyone else heard anything about this?? ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
[Felvtalk] LTCI Rumor
I am hearing that after Sept or so, the new distributors of the LTCI will only sell 10 packs-this is going to make it very difficult for most of us to afford-plus the price went up. I think they are wanting the veterinarians to carry the product in stock-but I am thinking most won't - Like my vet...I researched and found the product and begged them to order it for me. Has anyone else heard anything about this?? ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
Re: [Felvtalk] Bustopher Jones Please add to the CLS :(
I'm so sorry to hear of Bustopher's passing; that's so sweet that he was able to cuddle up with another cat, instead of dying all alone. So many in the last two weeks I named a tiger kitten Bustifur a few years ago.it is a great name - rolls of your tongue nicely. Natalie -Original Message- From: felvtalk-boun...@felineleukemia.org [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Laurieskatz Sent: Friday, August 06, 2010 10:55 PM To: felvtalk@felineleukemia.org Subject: Re: [Felvtalk] Bustopher Jones Please add to the CLS :( What a great name! "Never, never be afraid to do what's right, especially if the well-being of a person or animal is at stake. Society's punishments are small compared to the wounds we inflict on our soul when we look the other way." ~ Martin Luther King, Jr. -Original Message- From: felvtalk-boun...@felineleukemia.org [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Beth Sent: Friday, August 06, 2010 3:45 PM To: felvtalk@felineleukemia.org Subject: Re: [Felvtalk] Bustopher Jones Please add to the CLS :( Sweet baby. At least he went in his sleep. Beth Dont Litter, Fix Your Critter! www.Furkids.org --- On Thu, 8/5/10, Sherry DeHaan wrote: From: Sherry DeHaan Subject: [Felvtalk] Bustopher Jones Please add to the CLS :( To: "Felvtalk" Date: Thursday, August 5, 2010, 10:51 PM What can say about sweet Bustopher? This WONDERFUL tiger boy won all out hearts with his Koala bear hugs.Once he latched on he would not let go. I went in for my volunteer shift tonight and saw in the log book that he had passed away all of a sudden in his sleep. He was fine just before the last shift left and when one of the ladies came in to do her Cat checks thats when she found him,he was cuddled up with Hogan(whom he ALWAYS cuddled with),he was still a bit warm,but he had passed. :( Dr Jen is out of town on vacation with her family and not sure if she knows yet. Oh Bustopher you will be missed by MANY MANY of us. Sherry "We who choose to surround ourselves with lives more temporary than our own, Live within a fragile circle,easily and often breached. Unable to accept its awful gaps. We still would have it no other way" ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
Re: [Felvtalk] Murphy-PCV is up to 27-28 but has a fever
Alice I am not sure of Murphy's history, but our cat ran an unexplained fever of 104 for a year. He has been on high dosages of Pred for 1.5 years. His temp is back to normal. There was never an answer for the temp. Sent from my iPhone On Aug 6, 2010, at 6:33 PM, Alice Flowers wrote: > What the heck-we can't get well!!! His gums are looking nice and pink-his PCV > in > the office is up to 27-28 from 2 weeks ago. His temp was 104.7 today when it > had > been 101.6 the last 2 visits-7/23 and 7/29. That explains his dry, warm nose. > They gave him a shot of PennG and I will repeat in 5 days at home and to keep > him on all the meds like we have been the last 2 weeks. He's been on > Doxycycline > for 2 weeks. He is down only 2.5 oz but overall has gone from 11 lb 15 oz in > November to 10 lb 2 oz today. He looks bright, but is sleeping a lot. I don't > get it-what is causing the fever??? > ___ > Felvtalk mailing list > Felvtalk@felineleukemia.org > http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
