Filip:
In your case it may be that conditional means are more appropriate than
conditional modes, but I would not necessarily conclude that in general.
I do not know what Monolix reports regarding individual parameters.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics, R&D
ICON Development
Hi Bob,
Thanks for the clarification. Would you agree that the conditional means are
more trustworthy, in case there is a relevant difference? In my specific
dataset, there are 5 subjects for whom the conditional means yield a much
better individual fit, than the "post-hoc" eta's.
I believe
Filip:
The $TABLE results are obtained from a "post-hoc" assessment at the best fit
eta values (modal, EBE), regardless of the method used. To evaluate $TABLE
parameters at the conditional mean positions, you may select FNLETA=0.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics, R&D
ICON
Dear All,
With NM7.2/SAEM, the root.phi output file contains the conditional means
(and variances) of the individual phi's (mu(i)+eta(i)) - which is great!
I found that the these values can be different from what you get from a
$TABLE in more classical way:
$PRED
MU_1=THETA(1)
K=MU_1+ETA
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