RE: [NMusers] Reporting Modeling Results

, James James G Wright PhD Scientist Wright Dose Ltd Tel: 44 (0) 772 5636914 www.wright-dose.com -Original Message- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Stephen Duffull Sent: 25 October 2007 23:53 To: 'Mark Sale - Next Level Solutions' Cc: 'nmusers' Subject: RE

RE: [NMusers] Reporting Modeling Results

be correct. Did any adverse events occur in the 4 excluded subjects in the novel treatment arm? This is all I wish to know. Best regards, James James G Wright PhD Scientist Wright Dose Ltd Tel: 44 (0) 772 5636914 www.wright-dose.com -Original Message- From: [EMAIL PROTECTED] [mailto

RE: [NMusers] Your suggestions/thoughts needed on allometric base or final model

as to be practically irrelevant But that is a long way from: Weight is always important, in that it should alter dose selection Best regards, James James G Wright PhD Scientist Wright Dose Ltd Tel: 44 (0) 772 5636914 -Original Message- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf

RE: [NMusers] algorithm limits

. Best regards, James G Wright PhD Scientist Wright Dose Ltd Tel: 44 (0) 772 5636914 -Original Message- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Mark Sale - Next Level Solutions Sent: 19 July 2008 21:13 Cc: nmusers@globomaxnm.com Subject: [NMusers] algorithm

RE: [NMusers] Simultaneous vs sequential for modeling parent AND metabolites in pop PK

for the metabolite, but the importance of this depends on how the parameter will actually be used. James G Wright PhD Scientist Wright Dose Ltd Tel: 44 (0) 772 5636914 -Original Message- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Nick Holford Sent: 09 December 2008 20:52 To: nmusers

RE: [NMusers] Simultaneous vs sequential for modeling parent AND metabolites in pop PK

no end of stress over the years, and next time I may have to contend with the (almost irrefutable) argument but Nick Holford said it was true. Best regards, James James G Wright wrote: Hi Nick, I hope all is well with you - good to see you are keeping the nmusers in line :-). I am not sure I

RE: [NMusers] Simultaneous vs sequential for modeling parent AND metabolites in pop PK

that becomes metabolite is unknown - we are estimating CL/F, V/F etc. for the metabolite. Any assumption about F, V etc. is again optional. Do you agree? Best regards, James James G Wright PhD Scientist Wright Dose Ltd Tel: 44 (0) 772 5636914 -Original Message- From: [EMAIL PROTECTED

RE: Re: [NMusers] Simultaneous vs sequential for modeling parent AND metabolites in pop PK

on which assumptions are necessary and which are optional. I am pleased we are in agreement that assumptions about F= are entirely optional. Best regards, James James G Wright PhD Scientist Wright Dose Ltd Tel: 44 (0) 772 5636914 -Original Message- From: [EMAIL PROTECTED] [mailto:[EMAIL

RE: [NMusers] estimating Ka from dataset combining rich sample study and sparse sampling study

. It is likely that study procedures, precision of recorded sampling times etc. vary between the two studiess. Best regards, James James G Wright PhD Scientist Wright Dose Ltd Tel: 44 (0) 772 5636914 -Original Message- From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com

RE: [NMusers] What does convergence/covariance show?

Hi Nick, I hope you are well. I think what you have written below is very nice summary of a sensible and realistic approach to extrapolation, and I just wanted to add a comment from my personal experience. On a couple of occasions, I have seen data which unexpectedly switches from linear to

Re: [NMusers] The theory of relativity for CL and V...

, The pharmacometrics group at the University of Cape Town -- James G Wright PhD, Scientist, Wright Dose Ltd Tel: UK (0)772 5636914

Re: [NMusers] The theory of relativity for CL and V...

it separately for pure CL and F... Maybe I can put in the table all the NONMEM pure values and show CL/F explicitly in the text? In the end the values of V/F, Q/F, etc are not as important as CL/F. Thanks again! Paolo On 2013/01/07 16:39, James G Wright wrote: Dear Paolo, If I have

Re: [NMusers] how to model blood volume change during and after hemodialysis?

immediately notify the sender and thereafter delete this email and any attachments. -- James G Wright PhD, Scientist, Wright Dose Ltd Tel: UK (0)772 5636914

Re: [NMusers] how to model blood volume change during and after hemodialysis?

: Alpenstrasse 3 8152 Glattpark-Opfikon (Zürich) Switzerland Phone: (+41) 44 / 55 51 404 Mobile: (+41) 79 / 654 33 99 mailto: nele.kaess...@takeda.com http://www.takeda.com -Original Message- From: James G Wright [mailto:ja...@wright-dose.com] Sent: Freitag, 18. Januar 2013 5:10 To: Kaessner

Re: [NMusers] seeking help on NONMEM code for simulation of Repeated Time to Event Data

not have a closed form (i.e. only expressed in differential equation), how can I do that? Your help will be much appreciated! Yaming Hang -- James G Wright PhD, Scientist, Wright Dose Ltd Tel: UK (0)772 5636914

[NMusers] Opportunities at Wright Dose

-dose.com, indicating if we may retain a copy in the event we are unable to offer you one of our current positions. Please also include your notice period. All applications will be treated with the utmost confidentiality. -- James G Wright PhD, Scientist, Wright Dose Ltd Tel: UK (0)772 5636914

Re: [NMusers] Random effect on ALAG between dose events

flect "inter dose event variability" either. I was wondering if there is any good solution to this problem? Any comments are very much appreciated! Warm regards, Tingjie Guo -- James G Wright PhD, Scientist, Wright Dose Ltd Tel: UK (0)772 5636914

Re: [NMusers] Observed (yaxis) vs Predicted (xaxis) Diagnostic Plot - Scientific basis.

between the two approaches is different. This is the statistical reason why it matters to plot predictions on the xaxis. Joga Gobburu University of Maryland -- James G Wright PhD, Scientist, Wright Dose Ltd Tel: UK (0)772 5636914

Fwd: [NMusers] Observed (yaxis) vs Predicted (xaxis) Diagnostic Plot - Scientific basis.

Hi Nick, I hope you are well!  I think censoring is still a problem for VPCs unless you are including am explicit model component for the mechanism of  censoring…? I agree that the VPC is the most important method of assessing your model, and diagnostic plots are mainly to help you work out

Re: [NMusers] OFV by endpoint of joint models?

University means that we will process your personal data. For more information on how this is performed, please read here: http://www.uu.se/en/about-uu/data-protection-policy -- James G Wright PhD, Scientist, Wright Dose Ltd Tel: UK (0)772 5636914