There are several things which make me question this study.

First it is In Vitro, which does not necessarily correspond to in vivo application.

Second this was done with a growing culture. That is tremendously different than tissue that is not growing. For instance in an adult there are three things which are continually growing, hair, fingernails, and the dermis. And as we know any sign of argyria shows up in these three areas. That is silver tends to be captured by growing tissue. So although this might apply to a fetus, it certainly does not to an adult.

Third they say that this solution is citrate stabilized. This doesn't make a lot of sense to me. It sounds like they are saying that silver ions present are reacted with citric acid to produce silver citrate to maintain solubility. This should have nothing to do with the particles, which they are suppose to be studying. However it is known that silver citrate transverses barriers in the body that most other forms of silver do not. This is a concern.

Fourth they indicate that they are adding silver nitrate to the particle solution. This, if I am reading it correctly, completely invalidates the results, since the nitrate is highly toxic to tissues, and very prone to plating out on the particles making them grow (photo development process).

Fifth, they attribute the toxicity of silver nitrate to the silver ions, which is incorrect, the toxicity is from the nitrate ion. Other forms of silver, such as silver oxide, silver hydroxide, silver citrate and so forth do not have this toxicity.

Because of the above, I think it is impossible to draw any conclusions when applied to normal usage of colloidal silver.

Marshall




On 12/17/2014 11:50 AM, Tam Gray wrote:
Can you translate this? In conclusion, what does this mean for a Joe like myself?

On Wed, Dec 17, 2014 at 7:03 AM, André Juthe <[email protected] <mailto:[email protected]>> wrote:

    
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0105359&representation=PDF
    
<http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0105359&representation=PDF>

    
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0058211&representation=PDF
    
<http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0058211&representation=PDF>

    /André



--
~Tam
www.tamgrayphotography.com <http://www.tamgrayphotography.com>