Silver nitrate has two ions, silver and the nitrate. Compounds of
silver, such as silver citrate, silver acetate, silver chloride, silver
oxide and silver hydroxide are not particularly toxic. Nitrates on the
other hand are somewhat toxic. This includes hydrogen nitrate (aka
nitric acid), potassium nitrate (ORAL (LD50): Acute: 3750 mg/kg), sodium
nitrate (ORAL (LD50): Acute: 1267 mg/kg ), ammonium nitrate (Ammonium
nitrate: ORAL (LD50): Acute: 2217 mg/kg). Silver nitrate has a toxicity
of ORAL (LD50): Acute: 1173 mg/kg, which is right in line with the other
nitrates.
For compounds of silver (except silver nitrate), I find either the msds
shows N/A, or a health rating of 0 (which means benign), or in on one
MSDS sheet as being greater than 10 grams per kg. Note that table salt
is 3 gram per kg, so that means it is less toxic than table salt.
http://www.scielo.br/scielo.php?pid=S1517-83822010000300033&script=sci_arttext
Silver-based antimicrobials can be effective in the treatment of
infections on account non-toxicity of active Ag^+ to human cells (4)
I had read that the nitrate ion is responsible for the toxicity of
silver nitrate long ago, but am unable to find the reference now.
Marshall
On 12/17/2014 2:11 PM, André Juthe wrote:
Thank you Marshall, for your review. There is also the concern with
the dose, while a certain dose maybe very harmful for a foetus, it may
be completely non-harmful for a being with larger size, even if the
dose is proportional to the size. Not every compound operate
proportional to the size of the individual.
However, do you have any reference to the claim that toxicity is from
the nitrate ion and not the other types of silver you mentions?
/André
2014-12-17 20:03 GMT+01:00 Marshall <[email protected]
<mailto:[email protected]>>:
There are several things which make me question this study.
First it is In Vitro, which does not necessarily correspond to in
vivo application.
Second this was done with a growing culture. That is tremendously
different than tissue that is not growing. For instance in an
adult there are three things which are continually growing, hair,
fingernails, and the dermis. And as we know any sign of argyria
shows up in these three areas. That is silver tends to be
captured by growing tissue. So although this might apply to a
fetus, it certainly does not to an adult.
Third they say that this solution is citrate stabilized. This
doesn't make a lot of sense to me. It sounds like they are saying
that silver ions present are reacted with citric acid to produce
silver citrate to maintain solubility. This should have nothing
to do with the particles, which they are suppose to be studying.
However it is known that silver citrate transverses barriers in
the body that most other forms of silver do not. This is a concern.
Fourth they indicate that they are adding silver nitrate to the
particle solution. This, if I am reading it correctly, completely
invalidates the results, since the nitrate is highly toxic to
tissues, and very prone to plating out on the particles making
them grow (photo development process).
Fifth, they attribute the toxicity of silver nitrate to the silver
ions, which is incorrect, the toxicity is from the nitrate ion.
Other forms of silver, such as silver oxide, silver hydroxide,
silver citrate and so forth do not have this toxicity.
Because of the above, I think it is impossible to draw any
conclusions when applied to normal usage of colloidal silver.
Marshall
On 12/17/2014 11:50 AM, Tam Gray wrote:
Can you translate this? In conclusion, what does this mean for a
Joe like myself?
On Wed, Dec 17, 2014 at 7:03 AM, André Juthe
<[email protected] <mailto:[email protected]>> wrote:
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0105359&representation=PDF
<http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0105359&representation=PDF>
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0058211&representation=PDF
<http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0058211&representation=PDF>
/André
--
~Tam
www.tamgrayphotography.com <http://www.tamgrayphotography.com>
