Thanks JD

The piece I wrote about Covid is a synthesis of a long investigation.  I have scores of references I didnt include.  But if the subject strikes a chord, an interested person could go on an endless journey looking at the multi phase characteristic of covid and the many implications of treatments, vaccines and public health.  An under represented aspect of Covid.

Regarding complexing silver with herb extracts.  I anticipate this is going to be a controversy with this silver list.  It appears that most believe silver is totally benign, and any consideration of silver toxicity and ways to mediate it may be met with derision. So I acknowledge their strong beliefs but encourage an open mind.  I emphasize that Im not arguing for any view or inciting argument or conflict.  Biology is too huge and complex a subject to make definitive claims.

When I research the toxicity of silver in aquatic systems, it leaves little doubt in my mind there is a toxicity problem for many aquatic species including fish.  In fish and amphibian toxicity tests with 22 metals and metalloids, Silver was the most toxic tested element.   Likewise the potential for human toxicity is not resolved.  There are articles like this one which I read on Sci-hub which cover some of the points

  Adverse effects of nanosilver on human health and the environment
 Rezvani, Kennedy et al

For me, there is a precautionary principle I invoke which is that we normally get up to several 10s of micrograms of silver from food. So when I started to see the many papers springing up in pubmed claiming less toxicity and even enhanced effectiveness it was intuitively attractive. Our evolutionary exposure to silver will normally be complexed with plants, so it makes sense our biology would be tuned to this form.  Reasons why this may be so go beyond our limited imagination.

Silver has some extraordinary bio reactivity.  Robert Becker had great success in limb and bone regeneration using silver partly because silver can de-differentiate cells. 'Effects of electrically generated silver ions on human cells and wound healing'
July 2009Electromagnetic Biology and Medicine 19(1):1-19
Robert O. Becker

a recent study
Effects of electrical biostimulation and silver ions on porcine fibroblast cells
Yuanfeng Zhao,

and
Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy
Jae Woong

"The AgNPs showed typical crystalline structures and spherical shapes (average size =20 nm). High concentration of AgNPs induced cytotoxicity in a dose-dependent manner by increasing lactate dehydrogenase leakage and reactive oxygen species. Furthermore, AgNPs caused mitochondrial dysfunction, DNA fragmentation, increased expression of apoptotic genes, and decreased expression of antiapoptotic genes. Lower concentrations of AgNPs induced neuronal differentiation by increasing the expression of differentiation markers and decreasing the expression of stem cell markers"

So the possibility that my colloidal silver could de differentiate or otherwise fold spindle or mutilate my neural cells has been in the back of my mind longer than I can remember (joke).  My father died with an unknown problem in his brain which destroyed his balance and muscle use.  He had showed me how a colloidal silver sort of poultice had changed the skin on his arm, leaving a large area slightly raised and unpigmented with some granulation.  We didnt know what to make of it.   I have continued to use silver over the decades since then but I have been a little wary to give it to others with full confidence it is completely non toxic.

How I complexed silver with witch hazel.  Not very scientifically! I chose witch hazel because it has one of the highest scores at reducing peroxynitrite, one of the worst free radicals.  I arbitrarily added about five tablespoons of aquious/alcohol extract to a quart of my home brewed colloidal/ionic  silver.  I let this sit for six months and observed that it seemed stable and nothing fell out of suspension.  There was a slight haze.   I dont know if complexing silver with herb extract will make it better or less toxic, but the literature seems to point in that direction.

http://www.ncbi.nlm.nih.gov/pubmed/25022503

http://www.ncbi.nlm.nih.gov/pubmed/26196716

http://www.ncbi.nlm.nih.gov/pubmed/25147142

http://www.ncbi.nlm.nih.gov/pubmed/25189525

http://www.ncbi.nlm.nih.gov/pubmed/23270884

Silver Nanoparticles: Mechanism of Action and Probable Bio-Application
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711612/


Anti-biofilm and Antibacterial Activities of Silver Nanoparticles Synthesized by the Reducing Activity of Phytoconstituents Present in the Indian Medicinal Plants
https://www.frontiersin.org/articles/10.3389/fmicb.2020.01143/full

Medicinal Plant Leaf Extract and Pure Flavonoid Mediated Green Synthesis of Silver Nanoparticles and their Enhanced Antibacterial Property
https://www.nature.com/articles/s41598-017-15724-8


thanks

Max






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