"Jim Holmes" <[email protected]> wrote: Me wrote:
> "Sublingual absorption is much more effective than drinking it." > Do you have any documentation to support that. I suspect it is > true, and would like to verify that. > Jim Yes, the pharmaceutical industry has done many studies on the effectiveness of sublingual absorption. For example, nitroglycerin for stimulating the heart is universally taken sublingually. Here are a few references that might be of interest. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Selected References on Sublingual Absorption The principle behind sublingual administration is fairly simple. When a chemical comes in contact with the mucous membrane, or buccal mucosa, it diffuses into the epithelium beneath the tongue. This region contains a high density of blood vessels, and as a result, via osmosis, the substance quickly enters the blood stream at the sublingual artery. Quickly thereafter, the substance is carried by blood flow to the connected lingual artery, which takes up the chemical and translates it to its source: the carotid artery. http://en.wikipedia.org/wiki/Sublingual One of the best known drugs used regularly with great success is Glyceryl Trinitrate - a potent coronary vasodilator which is used for the rapid symptomatic relief of angina. It has been found impressively effective when administered sublingually; pharmacologically active after only 1 - 2 minutes. http://www.positivehealth.com/permit/articles/Colon%20Health/lea13. htm Sublingual drug delivery refers to any method of administering medicine so that it can be absorbed directly into the bloodstream through the rich layers of blood vessels found on the bottom of the tongue. Compared to commonly used tablets, capsules and other oral dosage forms, sublingual absorption is generally much faster and more efficient. Products passing through the digestive tract are subject to a "first pass" effect, in which many of the ingredients may be broken down by stomach acid or metabolized by the liver. Peak blood levels of most products administered sublingually are achieved within 10-15 minutes, which is generally much faster than when those same drugs are ingested orally. Sublingual absorption is efficient. The percent of each dose absorbed is generally higher than that achieved by means of oral ingestion. http://www.gelstat.com/oradose.asp Original Viagra is absorbed through the gut and takes 60-90 minutes to take effect, thereby eliminating any spontaneity in the sexual encounter. Sublingual absorption revolutionized the speed of Sildenafil Citrate. The new process decreases the time for the drug to be absorbed and weave its magic to as little as 15-20 minutes. http://www.soft-up.com/ Sublingual absorption is 3 to 10 times greater than oral administration absorption and is only surpassed by hypodermic injection. http://www.healingpeople.com/store/biomax.html If you take EDTA sublingually (under the tongue), your absorption level compared with oral chelation goes from 5-18 percent absorption for oral capsules to 60 percent for sublingual absorption. http://www.naturodoc.com/mm5/merchant.mvc? Screen=PROD&Store_Code=NATURODOC&Product_Code=DS-OraChel- 01&Category_Code=Vitamins Vitamin B-12 studies show that Sublingual B-12, B-6 & Folic Acid is readily absorbed into the bloodstream, raising blood levels on average by 90%. B-12 that is taken orally, not sublingually, only increases blood levels by 1.2%. http://www.home-base-business-advisor.com/sublingual-b12.html Advantages: First pass - The liver is by-passed thus there is no loss of drug by first pass effect for buccal administration. Bioavailability is higher. http://www.boomer.org/c/p1/Ch07/Ch0703.html ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Regards, Mike M. http://silversol.freewebpage.org/index.htm http://silversol.freewebpage.org/spice/xtal/clapp.htm -- The Silver List is a moderated forum for discussing Colloidal Silver. Instructions for unsubscribing are posted at: http://silverlist.org To post, address your message to: [email protected] Address Off-Topic messages to: [email protected] The Silver List and Off Topic List archives are currently down... List maintainer: Mike Devour <[email protected]>
