Hi Jimmy,
I have repeated the process from TPP. The command gets stuck either
after sending the Sequest search or creating the pepXML file. I might
have to reinstall pearl and TPP.
Antonio


On Jul 9, 2:41 pm, Antonio <[email protected]> wrote:
> Ok Jimmy,
> Thank you very much for your help.
> I'll repeat the entire process from TPP and I will let you know the
> result.
> Regards,
> Antonio
>
> On Jul 9, 2:18 pm, Jimmy Eng <[email protected]> wrote:
>
>
>
> > I guess the next step is to repeat the pepXML conversion from the GUI
> > and see if the GUI reports that the command completed successfully.  If
> > it does, organize a couple of search directories using the same
> > structure and repeat the pepXML conversion.  Still getting stuck or is
> > the processes reported to be completed?
>
> > If if looks like the first pepXML file is generated/completed but the
> > interface thinks the command is still running, I'm going to need Luis to
> > chime in on what to look for as I've exhausted the bits I have knowledge
> > of.  So let us know what happens when you try the above.
>
> > - Jimmy
>
> > Antonio wrote:
> > > Hi Jimmy,
>
> > > OK, done it. No problem, the command were successfull, all finished,
> > > th eTPP window indicated that the command was sucessfull and is
> > > finished. i can open the basename.pep on TPP and all seens OK.
> > > What next?
>
> > > Antonio
>
> > > On Jul 8, 12:33 pm, Jimmy Eng <[email protected]> wrote:
> > >> Antonio,
>
> > >> Can you try this.  Replace "basename" with one of your RAW/mzXML file
> > >> base name (i.e. <basename>.mzXML)
>
> > >> Collate data as
>
> > >>     c:/Inetpub/wwwroot/ISB/data/AAS/basename.mzXML
> > >>     c:/Inetpub/wwwroot/ISB/data/AAS/basename/  contains dta/out
> > >>     c:/Inetpub/wwwroot/ISB/data/AAS/sequest.params
>
> > >> Then in a command prompt run
>
> > >>     cd c:/Inetpub/wwwroot/ISB/data/AAS/
> > >>     Out2XML basename 1
>
> > >> This should create basename.pep.xml in the AAS directory.  This simple
> > >> exercise is just to confirm that it runs through correctly and the
> > >> process finishes.  The next thing to try is to repeat the above data
> > >> structure but try the pepXML conversion in the GUI.  Hopefully this
> > >> isolates whether you're experiencing a pepXML conversion problem or a
> > >> GUI problem.
>
> > >> - Jimmy
>
> > >> Antonio wrote:
> > >>> Hi Jimmy,
> > >>> I run Sequest from Bioworks on our computer cluster, and then transfer
> > >>> the files to the local machine running TPP, so yeas I had the c:/
> > >>> Inetpub/wwwroot/ISB/data/AAS/test/
> > >>> With the out-and dta- files in it.
> > >>> I have attempted to run Sequest from TPP and I had the same problem;
> > >>> the dta and out files are created, but the command indicates that is
> > >>> still running. The problem occurs whether I send a few files or a
> > >>> single one. But I have more than one file on the queue, the command
> > >>> will not proceed to the next file. I can run Sequest from Bioworks on
> > >>> the local machine without any problems.
> > >>> On Jul 2, 6:55 pm, Jimmy Eng <[email protected]> wrote:
> > >>>> Antonio,
> > >>>> That warning about not being able to open the mzXML file is not
> > >>>> indicative of the underlying problem.  It is truly just a warning and
> > >>>> the analysis process is capable of finishing correctly even if the
> > >>>> corresponding mzXML file is missing.
> > >>>> The important question that's not clear from your description below is
> > >>>> how did you run the Sequest search?  Did you run it separately via
> > >>>> Bioworks or did you run the search through the TPP?  Although helpful
> > >>>> but not required, it doesn't seem like you did the latter.  Do you have
> > >>>> a directory (e.g. c:/Inetpub/wwwroot/ISB/data/AAS/test/) that has the
> > >>>> Sequest .out files in it?
> > >>>> - Jimmy
> > >>>> Antonio wrote:
> > >>>>> I have installed TPP v4.2 on windows XP. I have created the mzXML
> > >>>>> datafiles from my Sequest search. Now I'm making the corresponding
> > >>>>> pepXML files. I see that the first file is being created, it seems
> > >>>>> that is finished but I see the following warming message at the end of
> > >>>>> the “Output so far” field:
> > >>>>> warning: cannot open mzXML file "c:/Inetpub/wwwroot/ISB/data/AAS/
> > >>>>> test.mzXML" for reading MS instrument info and scan times.
> > >>>>> And the command status window indicates that the command is still
> > >>>>> running. Is it? I do not see the file increasing in size. I can open
> > >>>>> the pepxml file, although IE indicates that there is an error on page.
> > >>>>> It seems to me that the program is stuck and is not progressing to
> > >>>>> next task: the creation of the next pepXML file. Solutions?
> > >>>>> Thanks,
> > >>>>>  Antonio- Hide quoted text -
> > >>>> - Show quoted text -- Hide quoted text -
> > >> - Show quoted text -- Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -

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