Hi all,

I posted my questions yesterday, but they were a bit too long to read,
so I shortened it (still seems long).

I am trying to use TPP (4.3.1) to run some cICAT data I collected a
while ago. All these cICAT data have been searched by Mascot (I have
all the .dat files). So far I have not got my data run by TPP on my
computer. Here are some questions.

1. If I have 1 mzXML file, a Mascot.dat file, and a database.fasta
file, are they enough to run TPP? (I guess so).

2. Does the database.fasta file has to be the exactly same
database.fasta file when I did Mascot searches (my data are a bit
old). I use SwissProt database. As I recall, when you update it, the
newer database overwrite the older one. So, can I use the Mascot.dat
files (searched against a older version SwissProt database) along with
the current database (newer version) to get TPP run? If not, where can
I download those older databases? I can not find them online.

3. I redid Mascot search anyway. With this new .dat file and the
SwissProt database.fasta file (for generating this .dat file), the TPP
still did not run. I  got following message:

c:/Inetpub/wwwroot/ISB/data/SSM4-1/F030337.pep.xml [ Unreadable! ]

command "c:\Inetpub\tpp-bin\Mascot2XML c:/Inetpub/wwwroot/ISB/data/
SSM4-1/F030337.dat -Dc:/Inetpub/wwwroot/ISB/data/SwissProt_57.12.fasta
-Etrypsin" failed: Operation not permitted
Command FAILED

I do not know how to fix it. It seems some permission issue? I looked
up a lot of old posts, seems no one ever mentioned this problem. Maybe
it is too simple to ask?

Any suggestion? Thanks a lot!

Fay

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