Hard to say what's going on.  Perhaps you could upload your new mascot
result file to the files area at
http://groups.google.com/group/spctools-discuss?hl=en. and someone can have
a look.

Brian

On Fri, Jun 18, 2010 at 11:09 AM, Fay Wang <[email protected]> wrote:

> Hi all,
>
> I posted my questions yesterday, but they were a bit too long to read,
> so I shortened it (still seems long).
>
> I am trying to use TPP (4.3.1) to run some cICAT data I collected a
> while ago. All these cICAT data have been searched by Mascot (I have
> all the .dat files). So far I have not got my data run by TPP on my
> computer. Here are some questions.
>
> 1. If I have 1 mzXML file, a Mascot.dat file, and a database.fasta
> file, are they enough to run TPP? (I guess so).
>
> 2. Does the database.fasta file has to be the exactly same
> database.fasta file when I did Mascot searches (my data are a bit
> old). I use SwissProt database. As I recall, when you update it, the
> newer database overwrite the older one. So, can I use the Mascot.dat
> files (searched against a older version SwissProt database) along with
> the current database (newer version) to get TPP run? If not, where can
> I download those older databases? I can not find them online.
>
> 3. I redid Mascot search anyway. With this new .dat file and the
> SwissProt database.fasta file (for generating this .dat file), the TPP
> still did not run. I  got following message:
>
> c:/Inetpub/wwwroot/ISB/data/SSM4-1/F030337.pep.xml [ Unreadable! ]
>
> command "c:\Inetpub\tpp-bin\Mascot2XML c:/Inetpub/wwwroot/ISB/data/
> SSM4-1/F030337.dat -Dc:/Inetpub/wwwroot/ISB/data/SwissProt_57.12.fasta
> -Etrypsin" failed: Operation not permitted
> Command FAILED
>
> I do not know how to fix it. It seems some permission issue? I looked
> up a lot of old posts, seems no one ever mentioned this problem. Maybe
> it is too simple to ask?
>
> Any suggestion? Thanks a lot!
>
> Fay
>
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