If you're running this using xinteract, you can debug a little by adding
"-t!" to the xinteract commandline on the release version, and "-t#" to the
commandline for the development version.  "-t!" (note the exclamation point)
causes a series of test files to be generated (they're just copies of the
output as the job progresses) and "-t#" causes the software to check its
progress against those files.  This may help you figure out where things are
going wrong.


On Wed, Jun 23, 2010 at 12:28 AM, Jagan Kommineni <[email protected]
> wrote:

> Dear All,
>
>            When I run the TPP pipeline with downloaded version of the
> development prerelease of TPP dated 22-04-2010, I am getting 0 hits
> whereas when I run pipeline with release version of TPP (TPP v4.3
> (jetstream)  rev 1) for the same data and parameters, I am getting 822
> hits.
>
>
> ------------------------------------------------------------------------------------------------------------------------------------------------------------------
>            Here is the STDOUT when I run the TPP pipeline with
> development version downloaded on 22-04-2010
>
> ----------------------------------------------------------------------------------------------------------------------------------------------------------------------
> /home/APCF/tpp/bin/xinteract (TPP v4.4 JETSTREAM (unstable development
> prerelease) rev 0, Build 201006041141 (linux))
>
> running: "/mnt/sanfs/APCF/APCF_WEB/tpp/bin/InteractParser 'jagan-
> J78.pepprophet.xml' 'jagan-J78.pep.xml' -L'7'"
>
> file 1: jagan-J78.pep.xml
>
> processed altogether 3429 results
>
> results written to file /mnt/sanfs/APCF/results/tpp/2010-06-23/jagan-
> J78.pepprophet.shtml
>
> command completed in 1 sec
>
> running: "/mnt/sanfs/APCF/APCF_WEB/tpp/bin/PeptideProphetParser 'jagan-
> J78.pepprophet.xml' MINPROB=0.05 EXTRAITRS=20"
>
> (X! Tandem (k-score))
>
> init with X! Tandem (k-score) trypsin
>
> MS Instrument info: Manufacturer: Thermo Scientific, Model: LTQ
> Orbitrap, Ionization: nanoelectrospray, Analyzer: orbitrap, Detector:
> inductive detector
>
> Initialising statistical models ...
>
> Iterations: .........10.........20........
>
> model complete after 29 iterations
>
> command completed in 0 sec
>
> running: "/mnt/sanfs/APCF/APCF_WEB/tpp/bin/ProphetModels.pl -i jagan-
> J78.pepprophet.xml"
>
> Analyzing jagan-J78.pepprophet.xml ...
>
> Parsing search results "jagan-J77 (X! Tandem (k-score))"...
>
> => Total of 0 hits.
>
> command completed in 0 sec
>
> running: "/mnt/sanfs/APCF/APCF_WEB/tpp/bin/DatabaseParser 'jagan-
> J78.pepprophet.xml'"
>
> command completed in 0 sec
>
> running: "/mnt/sanfs/APCF/APCF_WEB/tpp/bin/RefreshParser 'jagan-
> J78.pepprophet.xml' '/home/APCF/databases/SwissProt/
> uniprot_sprot.fasta'"
>
> - Searching the tree...
>
> - Linking duplicate entries... - Printing results...
>
> command completed in 3 sec
>
> running: "/mnt/sanfs/APCF/APCF_WEB/tpp/cgi-bin/PepXMLViewer.cgi -I /
> mnt/sanfs/APCF/results/tpp/2010-06-23/jagan-J78.pepprophet.xml"
>
> command "/mnt/sanfs/APCF/APCF_WEB/tpp/cgi-bin/PepXMLViewer.cgi -I /mnt/
> sanfs/APCF/results/tpp/2010-06-23/jagan-J78.pepprophet.xml" exited
> with non-zero exit code: 11
>
> QUIT - the job is incomplete
>
> ProteinProphet (C++) by Insilicos LLC and LabKey Software, after the
> original Perl by A. Keller (TPP v4.4 JETSTREAM (unstable development
> prerelease) rev 0, Build 201006041141 (linux))
>
> (xml input) (report Protein Length) (using degen pep info)
>
> . . . reading in /mnt/sanfs/APCF/results/tpp/2010-06-23/jagan-
> J78.pepprophet.xml. . .
>
> did not find any PeptideProphet results in input data! Did you forget
> to run PeptideProphet?
>
> . . . read in 0 1+, 0 2+, 0 3+, 0 4+, 0 5+, 0 6+, 0 7+ spectra with
> min prob 0.05
>
> no data - quitting
>
> ==============================================================================
> But when I run the same thing with release version of TPP (TPP v4.3
> (jetstream) rev 1) everything  went OK.
> Here is the STDOUT message ....
>
> ---------------------------------------------------------------------------------------------------------------------------------------------------------------
>
> [r...@compute-3-0 temp]# pwd
> /mnt/sanfs/APCF/results/tpp/2010-06-23/temp
> [r...@compute-3-0 temp]# ls
> jagan-J77.mzXML  jagan-J77.xml
> [r...@compute-3-0 temp]# /share/apps/TPP431/trans_proteomic_pipeline/
> build/linux/Tandem2XML jagan-J77.xml jagan-J78.pep.xml
> [r...@compute-3-0 temp]# /share/apps/TPP431/trans_proteomic_pipeline/
> build/linux/InteractParser jagan-J78.pepprophet.xml jagan-J78.pep.xml -
> L7
>  file 1: jagan-J78.pep.xml
>  processed altogether 3429 results
>
>  results written to file /mnt/sanfs/APCF/results/tpp/2010-06-23/temp/
> jagan-J78.pepprophet.shtml
>
> [r...@compute-3-0 temp]# /share/apps/TPP431/trans_proteomic_pipeline/
> build/linux/PeptideProphetParser jagan-J78.pepprophet.xml MINPROB=0.05
> EXTRAITRS=20
>  (X! Tandem (k-score))
> init with X! Tandem (k-score) trypsin
> MS Instrument info: Manufacturer: Thermo Scientific, Model: LTQ
> Orbitrap, Ionization: nanoelectrospray, Analyzer: orbitrap, Detector:
> inductive detector
>
>  PeptideProphet  (TPP v4.3 JETSTREAM rev 1, Build 201003241044
> (linux)) akel...@isb
>  read in 1127 1+, 1355 2+, 361 3+, 54 4+, 0 5+, 0 6+, and 0 7+
> spectra.
> Initialising statistical models ...
> negmean = -0.490485
> negmean = -0.0225753
> negmean = -0.520051
> negmean = 0.801738
> negmean = -0.2
> negmean = -0.2
> negmean = -0.2
> Iterations: .........10.........20........
> WARNING: Mixture model quality test failed for charge (1+).
> model complete after 29 iterations
> [r...@compute-3-0 temp]# /share/apps/TPP431/trans_proteomic_pipeline/
> build/linux/ProphetModels.pl -i jagan-J78.pepprophet.xml
> Analyzing jagan-J78.pepprophet.xml ...
> Parsing search results "jagan-J77 (X! Tandem (k-score))"...
>  => Total of 822 hits.
> [r...@compute-3-0 temp]# /share/apps/TPP431/trans_proteomic_pipeline/
> build/linux/DatabaseParser jagan-J78.pepprophet.xml
> /home/APCF/databases/SwissProt/uniprot_sprot.fasta
> [r...@compute-3-0 temp]# /share/apps/TPP431/trans_proteomic_pipeline/
> build/linux/RefreshParser jagan-J78.pepprophet.xml /home/APCF/
> databases/SwissProt/uniprot_sprot.fasta
>  - Building Commentz-Walter keyword tree...  - Searching the tree...
>  - Linking duplicate entries...  - Printing results...
> [r...@compute-3-0 temp]#
>
> ==============================================================================
>
> I wonder whether there is any quick fix to this problem. Something
> broken from the release version to development version.
>
> with regards,
>
> Jagan Kommineni
>
>
>
>
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