Hi Chris,

I downloaded and installed 4.4 on my development machine and I see the same issue. It's clear what the problem is though: the MSFileReader.XRawfile2.SxS.manifest and Interop.EDAL.SxS.manifest files are not included in the installation. They must be kept side by side with the msconvert executable. An official fix will require a TPP patch, but in the meantime, you can download these files directly from ProteoWizard and put them in your tpp-bin directory:
http://proteowizard.svn.sourceforge.net/viewvc/proteowizard/trunk/pwiz/pwiz/utility/vendor_api/thermo/MSFileReader.XRawfile2.SxS.manifest
http://proteowizard.svn.sourceforge.net/viewvc/proteowizard/trunk/pwiz/pwiz_aux/msrc/utility/vendor_api/Bruker/Interop.EDAL.SxS.manifest

-Matt


On 8/24/2010 9:19 AM, chr12is wrote:
Hi,

I am having a problem with MSConvert getting my files to mzML.  I
recently upgraded to TPP 4.4 from 4.3.1.  The previous version of the
TPP was working fine on this system.  I am running in to the same
problem on two systems, one with Windows Server 2008, and one with
Windows 7, both 64-bit systems, only one of which is running anti-
virus.

My problem is since the upgrade of the TPP, msconvert simply will not
run.  I get a side by side configuration error.  I have checked the
manifest for msconvert, and I have the correct visual studio files
installed for it to function.  When I go to the error viewer, this is
the output that is given:

Activation context generation failed for "C:\Inetpub\tpp-bin
\msconvert.exe". Dependent Assembly
MSFileReader.XRawfile2.SxS,type="win32",version="2.1.0.20" could not
be found. Please use sxstrace.exe for detailed diagnosis.

I have tried uninstalling and reinstalling the TPP using the right
click "run as administrator" option to no avail. I am trying to
convert Waters .raw folders and I have MassLynx and ProteinLynx
installed on the systems. This is only a problem with msconvert.  All
of the other binaries seem to run fine, from the ones I have tested.
Can anyone shed some light on what might be happening here?

Thanks!

Chris


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