hey jimmy,

thanks for the reply!
i tried to follow your advice wtih modifying the pepxml produced by crux.
however it seems i am not pulling the right strings.

when having a crux header like this:

<?xml version="1.0" encoding="UTF-8"?>
<?xml-stylesheet type="text/xsl" href="">
<msms_pipeline_analysis date="Tue Feb  1 23:30:51 2011
" xmlns="" xmlns:xsi="" xsi:schemaLocation="" summary_xml="">
<msms_run_summary
base_name="/cluster/scratch/malars/mzxml/plasmaprot/B08-02057.mzXML"
msManufacturer="NA" msModel="NA" msIonization="NA" msAnalyzer="NA"
msDectector="NA" raw_data_type="NA" raw_data="NA" >
<sample_enzyme name="trypsin">
</sample_enzyme>
<search_summary
base_name="/cluster/scratch/malars/mzxml/plasmaprot/B08-02057.mzXML"
search_engine="Crux" precursor_mass_type="average"
fragment_mass_type="monoisotopic" out_data_type="NA" out_data="NA"
search_id="1" >
<search_database
local_path="/cluster/scratch/malars/databases/AE004092_sp_9606.idx/AE004092_sp_9606-binary-fasta"
type="AA" />
<enzymatic_search_constraint enzyme="trypsin" max_num_internal_cleavages="0"
min_number_termini="2"/>
<aminoacid_modification aminoacid="C" mass="160.160263" massdiff="57.021464"
variable="N" />
<parameter name="fragment-mass" value="mono"/>

i tried various modifications of the msms_run_summary and the search_summary
tags but i always get the same error:

read no data

[quandtan@brutus2 crux-output]$ xinteract -dDECOY_ -OAdlIw
search.mod.pep.xml

running: "/cluster/apps/tpp/4.4.1/bin/PeptideProphetParser
'interact.pep.xml' DECOY=DECOY_ ACCMASS DECOYPROBS LEAVE PI INSTRWARN"
using Accurate Mass Bins
using pI
Using no error on different instrument types.
Using Decoy Label "DECOY_".
Decoy Probabilities will be reported.
 (SEQUEST) (leaving deltacn* entries)
adding Accurate Mass mixture distr
adding pI mixture distr
init with SEQUEST trypsin
MS Instrument info: Manufacturer: NA, Model: NA, Ionization: NA, Analyzer:
UNKNOWN, Detector: UNKNOWN

 PeptideProphet  (TPP v4.4 VUVUZELA rev 1, Build 201102011840 (linux))
AKeller@ISB
 read in 0 1+, 0 2+, 0 3+, 0 4+, 0 5+, 0 6+, and 0 7+ spectra.
 read in no data

command "/cluster/apps/tpp/4.4.1/bin/PeptideProphetParser 'interact.pep.xml'
DECOY=DECOY_ ACCMASS DECOYPROBS LEAVE PI INSTRWARN" exited with non-zero
exit code: 256


can you or probably david point me to what i am doing wrong?

cheers + thanks:-)
andreas


On Wed, Feb 2, 2011 at 2:35 AM, Jimmy Eng <[email protected]> wrote:

> Andreas,
>
> There's definitely no support for Crux in TPP 4.4.1 if that's what you
> tried.  The semi good news is that David does have code in the Sashimi
> SourceForge repository to start supporting Crux so maybe it'll work in
> the next full TPP release.  You might be able to push analysis through
> by editing your Crux pep.xml file and making it look like a Sequest
> pep.xml file for the time being.
>
> On Tue, Feb 1, 2011 at 3:18 PM, Andreas Quandt <[email protected]>
> wrote:
> > dear list,
> > i tried processing some pep.xml produced by crux with the tpp.
> > however i get always the same error message (i tried xinteract and the
> > peptideprophetparser both with the Pd option):
> > error: engine Crux not recognized
> > is the any possible chance to process these results with the tpp?
> > cheers,
> > andreas
> >
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