Hello,

I am trying the newest TPP installed on Win7 using the installer.  I have 
two small data sets of differentially labelled peptides searched separately 
with Tandem where one search specifies all light and the second all heavy 
labelled modifications.  When running ASAPRatio, I select static 
modifications and tell it N-terminus & K are modified.  It is pulling the 
correct mods from the tandem result file. But I get "error: cannot have 
variablel modified n in static mode."   

This worked well with TPP 4.5.2, but now it isn't working.  Is the new 
version of Tandem using different defaults for mods?  I am not specifying 
any in the tandem.params file.  I get the following error: (relevant part 
of pipeline output below)
.
.
.

running: "C:/Inetpub/tpp-bin/ASAPRatioPeptideParser "TEST-HL-interact.pep.xml" 
-lnK -b -F -C -Z -r0.5 -S"
K 170.142 176.18
n 43.0548 49.0928
error: cannot have variable modified n in static mode

command "C:/Inetpub/tpp-bin/ASAPRatioPeptideParser "TEST-HL-interact.pep.xml" 
-lnK -b -F -C -Z -r0.5 -S" failed: Operation not permitted

command "C:/Inetpub/tpp-bin/ASAPRatioPeptideParser "TEST-HL-interact.pep.xml" 
-lnK -b -F -C -Z -r0.5 -S" exited with non-zero exit code: 1
QUIT - the job is incomplete

command "c:\Inetpub\tpp-bin\xinteract -NTEST-HL-interact.pep.xml -p0.05 -l6 -Op 
-I4 -I5 -A-lnK-b-F-C-Z-r0.5-S 
120827_S-Aorta_GuanidineExtract-RABA-QC01.tandem.pep.xml 
c:/Inetpub/wwwroot/ISB/data/projects/S_Aorta/120827_Guanidine/light/120827_S-Aorta_GuanidineExtract-RABA-QC01.tandem.pep.xml"
 failed: Operation not permitted



Thanks in advance for any help.

Brian

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