Hi Brian,

Have you tried removing the static option -S when running this command?

Thanks,
-David

On Tue, Aug 28, 2012 at 2:50 PM, Brian Hampton <[email protected]> wrote:

> Hello,
>
> I am trying the newest TPP installed on Win7 using the installer.  I have
> two small data sets of differentially labelled peptides searched separately
> with Tandem where one search specifies all light and the second all heavy
> labelled modifications.  When running ASAPRatio, I select static
> modifications and tell it N-terminus & K are modified.  It is pulling the
> correct mods from the tandem result file. But I get "error: cannot have
> variablel modified n in static mode."
>
> This worked well with TPP 4.5.2, but now it isn't working.  Is the new
> version of Tandem using different defaults for mods?  I am not specifying
> any in the tandem.params file.  I get the following error: (relevant part
> of pipeline output below)
> .
> .
> .
>
> running: "C:/Inetpub/tpp-bin/ASAPRatioPeptideParser 
> "TEST-HL-interact.pep.xml" -lnK -b -F -C -Z -r0.5 -S"
> K 170.142 176.18
> n 43.0548 49.0928
> error: cannot have variable modified n in static mode
>
> command "C:/Inetpub/tpp-bin/ASAPRatioPeptideParser "TEST-HL-interact.pep.xml" 
> -lnK -b -F -C -Z -r0.5 -S" failed: Operation not permitted
>
> command "C:/Inetpub/tpp-bin/ASAPRatioPeptideParser "TEST-HL-interact.pep.xml" 
> -lnK -b -F -C -Z -r0.5 -S" exited with non-zero exit code: 1
> QUIT - the job is incomplete
>
> command "c:\Inetpub\tpp-bin\xinteract -NTEST-HL-interact.pep.xml -p0.05 -l6 
> -Op -I4 -I5 -A-lnK-b-F-C-Z-r0.5-S 
> 120827_S-Aorta_GuanidineExtract-RABA-QC01.tandem.pep.xml 
> c:/Inetpub/wwwroot/ISB/data/projects/S_Aorta/120827_Guanidine/light/120827_S-Aorta_GuanidineExtract-RABA-QC01.tandem.pep.xml"
>  failed: Operation not permitted
>
>
>
> Thanks in advance for any help.
>
> Brian
>
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