Hello,
This step is failing because the database you used to search cannot be
found on the computer:

error: could not open database file
"o:/hoc/12112012/database/decoy_uniprot_mouse(180210).fasta" (No such
file or directory)

If you moved the database to another location, you should manually
update the pepXML file (15N_slice03_interact.pep.xml) to reflect the
new location and rerun the analysis (no need to rerun the search).
You can also run the RefreshParser command on the command-line to
update the database location.

Cheers,
--Luis


On Mon, Nov 12, 2012 at 1:47 AM, Michaela Filiou
<[email protected]> wrote:
> Hi everyone,
>
> We are using TPP to analyze data from 14N/15N Orbi-derived mass spectra
> (peptide extracts from trypsin digested gel slices).
> At the “Analyze Peptides” step, the command fails for some 15N pepxml files.
> With the corresponding 14N files the command works fine.
> Do you have any idea what the problem may be?
>
> Below is the complete output from the TPP analysis command failure
>
> Thanks a lot in advance!
>
> Michaela
>
>
> c:\Inetpub\tpp-bin\xinteract (TPP v4.6 OCCUPY rev 0, Build 201208170820
> (MinGW))
>
>
>
> running: "C:/Inetpub/tpp-bin/InteractParser "15N_slice03_interact.pep.xml"
> "hoc_protein_turnover_pnd28_03.xml" -L"7""
>
>  file 1: hoc_protein_turnover_pnd28_03.xml
>
>  processed altogether 8636 results
>
>
>
>
>
>  results written to file
> c:/Inetpub/wwwroot/ISB/data/tpp_data/hoc/12112012/15N_pepxml/15N_slice03_interact.pep.xml
>
>
>
>  direct your browser to
> http://pcj43/ISB/data/tpp_data/hoc/12112012/15N_pepxml/15N_slice03_interact.pep.shtml
>
>
>
>
>
>
>
> command completed in 5 sec
>
>
>
> running: "C:/Inetpub/tpp-bin/DatabaseParser "15N_slice03_interact.pep.xml""
>
> command completed in 0 sec
>
>
>
> running: "C:/Inetpub/tpp-bin/RefreshParser "15N_slice03_interact.pep.xml"
> "O:/hoc/12112012/database/decoy_uniprot_mouse(180210).fasta""
>
>   - Searching the tree...error: could not open database file
> "o:/hoc/12112012/database/decoy_uniprot_mouse(180210).fasta" (No such file
> or directory)
>
>   - Building Commentz-Walter keyword tree...
>
> command "C:/Inetpub/tpp-bin/RefreshParser "15N_slice03_interact.pep.xml"
> "O:/hoc/12112012/database/decoy_uniprot_mouse(180210).fasta"" failed:
> Unknown error
>
>
>
> command "C:/Inetpub/tpp-bin/RefreshParser "15N_slice03_interact.pep.xml"
> "O:/hoc/12112012/database/decoy_uniprot_mouse(180210).fasta"" exited with
> non-zero exit code: -1
>
> QUIT - the job is incomplete
>
>
>
> command "c:\Inetpub\tpp-bin\xinteract -N15N_slice03_interact.pep.xml -p0.05
> -l7 -O -dREV: hoc_protein_turnover_pnd28_03.xml" failed: Unknown error
>
>
>
>
>
> Command FAILED
> RETURN CODE:65280
>
>
>
>
>
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