Hi all! My name is Antonio Ortega, and I am a Master student in 
Bioinfomatics at the University of Copenhagen, currently doing my Master 
Thesis on proteomics and mass spectrometry.

I was wondering how can I use StPeter as a quantification tool if I pass as 
input the output of search engines like MSGF or Comet. I can see in the 
tutorial that Stpeter receives as input protXML files, however Comet 
produces pepXML output and MSGF produces mzid files that apparently can be 
converted to pepXML with idconvert

https://groups.google.com/forum/#!topic/spctools-discuss/tbkcovbFxEc

Why is the intermediate proXML file produced by PeptideProphet, iProphet 
and ProteinProphet needed? Is there any step by step tutorial on how to use 
these tools from the command line? The tutorial 
here http://tools.proteomecenter.org/wiki/index.php?title=TPP_Tutorial 
applies for people using the GUI Petunia, however, Apache2 gives me a 
forbidden access error when I try to access the TPP port., so  I cannot 
follow the instructions there.

Regarding the method, the fragment ion intensity of the j spectrum of 
peptide k corresponds to the intensity of the precursor that generated 
spectrum j right? And this number can be found in .mgf spectrum files as 
the second number in the PEPMASS field right?
PEPMASS=XXXX YYY
being YYY equal to the intensity.

Thank you very much for your help in advance and keep up the good work!

Best regards


Antonio
 

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