Hi Will,

Thanks for posting your question.
This is due to a timeout setting in the webserver.  Thankfully there is a
simple fix:

https://groups.google.com/g/spctools-discuss/c/ZNXMkdB9Y48/m/TYcnPIHgBwAJ

In Windows the steps are :

1. Edit this file:  C:\TPP\conf\httpd-tpp.conf .

2. Change the timeout to a large number of seconds:

     Timeout 864000

(this will set the timeout to 10 days!)

3. Restart the Apache webserver (you can also find it in Services)

Cheers,
-David

On Thu, Dec 16, 2021 at 8:20 AM Will Comstock <[email protected]> wrote:

> I have also been encountering this issue and would love to hear a
> solution. The search still reads as "Running" but simply stops searching
> any more mzML files. Depending on the size of my  files, the search times
> out at different points, but will almost never search more than 8 files at
> a time.
>
> Happy to provide an example dataset + parameters + FASTA file if anyone
> wants to try and replicate the timeout.
>
> -Will
>
> On Wednesday, November 10, 2021 at 1:32:09 AM UTC-5 [email protected]
> wrote:
>
>> Hi everyone,
>>
>> I've been using TPP for a little while now for the analysis of my data. I
>> have been using Comet to perform database searching on a large number of
>> mzml files and have noticed that the analysis will usually time out after
>> about 6 hours. In this case, I will remove the mzml files that have been
>> successfully processed and then re-run comet. Is this job time-out an
>> inherent part of TPP, or is it a setting that can be changed? If the
>> latter, are there any risks in running the analysis for over 6 hours?
>>
>> Thanks in advance for any advice
>> Steven
>>
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