There are certainly a few drawbacks to using Reply-To, but I can't remember the last time I was on a mailing list that didn't make use of it. Clearly, there's a very solid consensus out there that Reply-To is the way to go.
That may be because a large fraction of email lists use something like Yahoogroups, which often uses reply-to-group as a default setting, though thankfully Yahoo lets you turn that option off. -- Darren Duncan
