Fosinopril is an ACE (angiotenson channel blocker) and seems to work well without so much tiredness. Usually, a doctor does use a combination, as that way he can get better control without such a big dose of any single medicine. Most importantly...stay on the drugs.. Some people think that once they feel better, and the blood pressure comes down, that they can quit..only to have a very nasty rebound. take care. JOyce

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