At 03:18 AM 8/6/2012, Jojo Jaro wrote:

In my continuing seris of Posts, I will touch on the issue of Genetic Improbablity. The article below probably best describes this problem of genetic improbability. The Paper is a well-cited paper and should be worthy of sciencific acceptance from open minded folks here:

The problem is that the paper assumes errors. Garbage in, garbage out. Jojo, I've been watching this. You have swallowed a pile of highly defective argument.

From The Myth of Natural Origins; How Science Points to Divine Creation

Ashby Camp, Ktisis Publishing, Tempe, Arizona, 1994, pp. 53-57, used by permission.

[...]


Even on a theoretical level, it does not seem possible for mutations to account for the diversity of life on earth, at least not in the time available. According to Professor Ambrose, the minimum number of mutations necessary to produce the simplest new structure in an organism is five (Davis, 67-68; Bird, 1:88), but these five mutations must be the proper type and must affect five genes that are functionally related. Davis, 67-68. In other words, not just any five mutations will do. The odds against this occurring in a single organism are astronomical.

There is a lost consideration. Take a random combination of five letters. Not just any combination will form a functional word. However, there are many combinations that would form a word. There is an assumption here that the mutations to form a particular word must occur simultaneously. That's completely bogus.

Mutations of any kind are believed to occur once in every 100,000 gene replications (though some estimate they occur far less frequently). Davis, 68; Wysong, 272.

This would vary greatly with environment and the particular organism.

Assuming that the first single-celled organism had 10,000 genes, the same number as E. coli (Wysong, 113), one mutation would exist for every ten cells.

A "mutation" is a process. So what is being said is that there would be one mutation per ten cell replications.

Just note: the first living things, under most understandings, would certainly not be a "single-celled organism." It would be a self-replicating molecule, an enzyme that catalyzes its own production. It would not be something we would recognize as living. We don't recognize DNA as living, rather DNA can catalyze the assembly of elements that create something we recognize as living, but stripping this down to basics, the simplest element is something that reproduces itself, given the appropriate environment. DNA as we know it is probably far more complex than the original self-replicating molecule.

I'm not sure what definition of "mutation" is being used here, and this could be part of the problem. A change in the nucleotide sequence, something other than exact copying, is the simple definition. Call them "errors." Not all errors are expressed in the organism, and I suspect that "mutation" is being restricted to something expressed. It actually causes a change in function.

 Since only one mutation per 1,000 is non-harmful (Davis, 66),

I don't trust this figure. What research is it based upon? (No, I'm not looking it up today.) Note, again, this does not refer to changes. Further, the definition of mutation used in the original claim about once in every 100,000 gene replications may be different. If a mutation requires an expressed difference, what kind of difference?

I don't know what "harmful" means. Does it mean that any cell with that specific mutation will not function?

there would be only one non-harmful mutation in a population of 10,000 such cells. The odds that this one non-harmful mutation would affect a particular gene, however, is 1 in 10,000 (since there are 10,000 genes). Therefore, one would need a population of 100,000,000 cells before one of them would be expected to possess a non-harmful mutation of a specific gene.

The odds of a single cell possessing non-harmful mutations of five specific (functionally related) genes is the product of their separate probabilities. Morris, 63. In other words, the probability is 1 in 108 X 108 X 108 X 108 X 108, or 1 in 1040. If one hundred trillion (1014) bacteria were produced every second for five billion years (1017 seconds), the resulting population (1031) would be only 1/1,000,000,000 of what was needed!

There is a total imprecision of definition here. The claim of five genes needing to be changed simultaneously is highly suspect. There is a complete neglect of the vast amount of "junk DNA" present in the genome. "Junk DNA" may have been functional at one time, but expression was turned off. To turn expression on and off takes, if I'm correct, a single mutation.

It's a mess.

[...]
When one considers that a structure as "simple" as the wing on a fruit fly involves 30-40 genes (Bird, 1:88), it is mathematically absurd to think that random genetic mutations can account for the vast diversity of life on earth. Even Julian Huxley, a staunch evolutionist who made assumptions very favorable to the theory, computed the odds against the evolution of a horse to be 1 in 10300,000. Pitman, 68. If only more Christians had that kind of faith!

The problem with these calculations is that they assume only one possible "horse." Imagine you toss a coin many times, then you look in the sequence of coin tosses for some remarkable pattern of, say, 100 tosses. You then calculate the probability of *that pattern* arising by chance. You will conclude that it's impossible, by the argument being used.

Random genetic changes are only one part of the mechanism of evolution. The process is guided by results, i.e., by the mechanism of life and how it is impacted by the random changes. Populations diverge when they no longer gene-mix. E coli is already a very complex organism that shares genes, if I'm correct.

We don't understand the whole process, but ascribing it to "creation" simply begs the question. Created. Fine. *How?*

Treating a mystery as if it is a proof for something is a common logical error. A mystery is a mystery.

The *mechanism* of evolution is reasonably well understood, however, and post-hoc probability analyses, based on a highly biased selection of possible probabilities, are no help.

The first step is to understand how the characteristics of life are maintained by the genetic code, how life works *without* change. Then how the code changes. The code changes. We know that. Most of the changes are, in fact, completely harmless. (Well, maybe not. But not harmless changes are eliminated quickly, most of them, only a few would survive to birth in a human, for example.)

Postulating "creation by an intelligent being" as the mechanism of evolution, avoiding examination of the *mechanism of creation* -- as if it were simply magic or the equivalent -- postulating continual divine intervention in the mutation process that takes place with each individual, without actually doing the work to show that there is a non-random element in real mutations, is simple laziness.

Goddidit.

We may individually choose to stop investigation with such a conclusion, and that can sometimes be functional. But sitting here and imagining that nearly everyone who thinks about these problems is befogged because of their stupid belief in something radically improbable, according to your own biased analysis, is actually arrogance, and God doesn't like arrogance. Have a bit of humility, Jaro, it would benefit you.

Don't say you weren't warned.

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