Same for PKPDsim (when `seed` argument specified): all subjects sampled up front, so inserting / removing observations has no effect on sampled parameters.
Ron On Thu, Mar 9, 2017 at 3:56 PM, Kyle Baron <ky...@metrumrg.com> wrote: > > To Ruben's question: mrgsolve simulates the subjects up front as well. > The subjects are identical across runs if the seed and number of subjects > does not change. > > An illustration: > http://mrgsolve.github.io/2017/03/09/reproducible-results-with-set.seed/ > > Best regards, > Kyle > > > On Thu, Mar 9, 2017 at 5:11 PM, Faelens, Ruben (Belgium) < > ruben.fael...@sgs.com> wrote: > >> Hi Penny, >> >> >> >> Nonmem indeed calculates each subject one after the other. The random >> values will therefore change. Maybe you can set the random seed every time >> you simulate t=0, based on the subject ID? >> >> This may also depend on your data file; have you tried ordering on time >> (so the first 50 rows are all t=0 for subject 1 to 50) ? >> >> >> >> This largely depends on the simulation software and its design: >> >> As an example: Simulo samples all subjects together at simulation start, >> after which it runs the trial design; so the same subjects are sampled >> independent of subsequent trial design. >> >> >> >> I do not know about other tools (TS.2, simulx, mrgsolve), maybe the >> authors of these tools can specify? >> >> >> >> Kind regards, >> >> Ruben Faelens >> >> >> >> *From:* owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] >> *On Behalf Of *Zhu, Penny >> *Sent:* donderdag 9 maart 2017 19:19 >> *To:* nmusers@globomaxnm.com >> *Subject:* [NMusers] question about random seed for simulation >> >> >> >> Dear All >> >> I have finished a multiple dose simulation for 600 subjects and want to >> perform a single dose simulation (different sampling time) on the same >> subjects (same ETA as the first simulation). I used the same seed for the >> simulation step, it turned out the first subject was the same and the rest >> of the subjects are not and I am not sure whether this was due to the fact >> that the two simulation has different number TIME records. If so, I wonder >> what is the proper way to set the simulation seed so that the ETAs for the >> second simulation will be identical to the first one. >> >> >> >> I know that I could output the individual parameter estimate from the >> first simulation and import them into the second one. But I was thinking >> if the random seed can be synchronized between the two simulation, it could >> be an easier solution. >> >> >> >> Your help is very much appreciated! >> >> >> >> Thank you very much and best regards! >> >> >> >> *Penny (Peijuan) Zhu, Ph.D.* >> >> Associate Director Clinical Pharmacology >> >> >> >> Cell: 862-926-9079 <(862)%20926-9079> >> >> >> >> PD Bio-Pharma CDMA >> >> Sandoz >> >> 1N025, 100 College Road West >> >> Princeton, NJ 08540 >> >> >> >> >> >> >> Information in this email and any attachments is confidential and >> intended solely for the use of the individual(s) to whom it is addressed or >> otherwise directed. Please note that any views or opinions presented in >> this email are solely those of the author and do not necessarily represent >> those of the Company. Finally, the recipient should check this email and >> any attachments for the presence of viruses. The Company accepts no >> liability for any damage caused by any virus transmitted by this email. All >> SGS services are rendered in accordance with the applicable SGS conditions >> of service available on request and accessible at >> http://www.sgs.com/en/Terms-and-Conditions.aspx >> > > > > -- > Kyle Baron, PharmD, PhD > Senior Scientist > Metrum Research Group > >
