On 07/21/2004 02:58 PM, Jeff Browndyke, Ph.D. wrote:
Hello all,
Sorry in advance for the annoying newbie question but, can CARET / SUREfit
do the following:
1.) generate cortical thickness data for later use in VBM
No, but Freesurfer can.
2.) generate fMRI activity group maps based upon surface-based registration
Yes, and this is an area of rapid improvement at the moment (both caret5
and our atlases).
You can also map functional group maps based on volume-based
registration (e.g., if your group data is in a supported atlas space
such as SPM, afni, or 711-2B.
But if you have segmented all your subjects and registered them to an
atlas target, then you can map the individual subjects' functional data
onto their respective surfaces; apply the deformation map to the
resulting metric files; and average the deformed metric files.
3.) output surface-based fMRI data in a format usable by SPM or AFNI for
between-group analyses
I've bought into the relative superiority of surface-based registration for
cortical fMRI data, but I'm still at a loss as to how one could carry
surface registered fMRI data out to a logical extension and perform
between-group fMRI comparisons (e.g., normals vs. patient samples).
Any tips or redirects would be most appreciated.
Dr. Van Essen is writing a paper for Neuroimage on this subject, but I
don't know the target publication date. Perhaps he would be willing to
make a preprint version available to the list. (Or perhaps he's still
writing it. ;-) He's out of the office today, but will return tomorrow.
Sincerely,
Jeff Browndyke, Ph.D.
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