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Something I have never found to work to my satisfaction has been solvent flattening after molecular replacement where the model is somewhat partial (i.e. more than 20% of the new structure is not modeled by the MR solution). In a case I was trying out for someone else a few months back I used DM with a variety of automatic and more manually-generated solvent masks, and this produced no significant gain in the phases to my eyes. So I am left with the suspicion that I'm not using the best methods.
Does anyone have any advice ? - I've found Coulombe and Cygler's 1997 paper (Acta Cryst D53, 426-433) - but I imagine that there is other information out there that an hour's Googling has yet to turn up.
Thanks Phil Jeffrey Princeton, NJ
