On 13 Sep, Richard Gillilan wrote: > *** For details on how to be removed from this list visit the *** > *** CCP4 home page http://www.ccp4.ac.uk *** > > > > A lysine sidechain in my structure seems to have a large elongated > blob of density attached to the end in a T-shaped configuration. > The buffer only contains ammonium sulfate and Lithium Sulfate. Is > anyone aware of structures in which modified lysine has been > observed? What kinds of modifications are possible?
The lysine may be acytylated, as a possible sirtuin target. The sirtuin mechanism is related to that of ADP-ribosyl cyclase, which I worked on in your lab. It is worth a look ;-}. Regards, Michael L. Love Ph.D Department of Biophysics and Biophysical Chemistry School of Medicine Johns Hopkins University 725 N. Wolfe Street Room 608B WBSB Baltimore MD 21205-2185 Interoffice Mail: 608B WBSB, SoM office: 410-614-2267 lab: 410-614-3179 fax: 410-502-6910 cell: 443-824-3451 http://www.gnu-darwin.org/ > Richard Gillilan > MacCHESS > Cornell University -- Visit proclus realm! http://proclus.tripod.com/ -----BEGIN GEEK CODE BLOCK----- Version: 3.1 GMU/S d+@ s: a+ C++++ UBULI++++$ P+ L+++(++++) E--- W++ N- !o K- w--- !O M++@ V-- PS+++ PE Y+ PGP-- t+++(+) 5+++ X+ R tv-(--)@ b !DI D- G e++++ h--- r+++ y++++ ------END GEEK CODE BLOCK------
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