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Richard,
how about a carboxylated lysine (KCX)? Occurs among others in ureases
and hydantionases.
See a nice electron density for it in 1gkp or here:
http://www.sciencedirect.com/science?_ob=MiamiCaptionURL&_method=retrieve&_udi=B6WK7-462F3GJ-23&_image=fig6&_ba=6&_user=582538&_coverDate=06%2F28%2F2002&_alid=449014534&_rdoc=23&_fmt=full&_orig=search&_cdi=6899&view=c&_acct=C000029718&_version=1&_urlVersion=0&_userid=582538&md5=d2b024588a6333c52106e8cb2169b873
Still a mystery to me how this modification occurs deeply buried in the
enzyme...
Cheers
Jan
Richard Gillilan wrote:
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A lysine sidechain in my structure seems to have a large elongated
blob of density attached to the end in a T-shaped configuration.
The buffer only contains ammonium sulfate and Lithium Sulfate. Is
anyone aware of structures in which modified lysine has been observed?
What kinds of modifications are possible?
Richard Gillilan
MacCHESS
Cornell University
--
Jan Abendroth
Howard Hughes Medical Institute and
University of Washington
1959 NE Pacific Street, K-426
Box 357742
Seattle, WA-98195
phone: +1-206-616-4510
fax: +1-206-685-7002
