Hi Simon, you can't stop it - I asked the same question (with some more questions) some weeks ago.
You can find the original email and the tips I got for not-so-good resolution B-factor refinement here: http://www.mail-archive.com/ccp4bb@jiscmail.ac.uk/msg01224.html Good luck, Eva 2007/5/9, Kolstoe S.E. <[EMAIL PROTECTED]>:
Dear all, I have a structure at fairly low resolution that I am trying to refine with Refmac. I do not want to refine B factors so have arbitrarily set them all to 20 and then run refmac in the ccp4i GUI after deselecting the "refine temperature factors" box. However, when I look at the resulting pdb file my B factors vary from 2 to 90. Is Refmac just calculating my B factors or is it still refining them, and if the latter how can I stop it? Thanks, Simon