Dear colleagues, Is there any appropriate tool for docking an interacting protein to a relatively large protein-protein interface (>2500 A2). We are facing a hetero-oligomer for which we approximately know the interfaces as well as the structures of the individual protomers and would like to model the hetero-oligomer. I have done some small molecule docking before, but the size of the interface seem to be prohibitive for using the same tools in the case of such a protein-protein interaction. Any help or suggestion would be highly appreciated.
Best wishes Thomas
