Hello, we had a 124 aa target in Casp14, without any detectable homology to a known structure. Within the experimental errors, the AlphaFold2 model is identical to the NMR model we got. That was very convincing. Best wishes Wim
De: "Jon Cooper" <[email protected]> À: "CCP4BB" <[email protected]> Envoyé: Jeudi 3 Décembre 2020 21:55:38 Objet: Re: [ccp4bb] AlphaFold: more thinking and less pipetting (?) Hello. A quick look suggests that a lot of the test structures were solved by phaser or molrep, suggesting it is a very welcome improvement on homology modelling. It would be interesting to know how it performs with structures of new or uncertain fold, if there are any left these days. Without resorting to jokes about artificial intelligence, I couldn't make that out from the CASP14 website or the many excellent articles that have appeared. Best wishes, Jon Cooper. Sent from ProtonMail mobile -------- Original Message -------- On 3 Dec 2020, 11:17, Isabel Garcia-Saez < [email protected]> wrote: Dear all, Just commenting that after the stunning performance of AlphaFold that uses AI from Google maybe some of us we could dedicate ourselves to the noble art of gardening, baking, doing Chinese Calligraphy, enjoying the clouds pass or everything together (just in case I have already prepared my subscription to Netflix). [ https://www.nature.com/articles/d41586-020-03348-4 | https://www.nature.com/articles/d41586-020-03348-4 ] Well, I suppose that we still have the structures of complexes (at the moment). I am wondering how the labs will have access to this technology in the future (would it be for free coming from the company DeepMind - Google?). It seems that they have already published some code. Well, exciting times. Cheers, Isabel Isabel Garcia-Saez PhD Institut de Biologie Structurale Viral Infection and Cancer Group (VIC)-Cell Division Team 71, Avenue des Martyrs CS 10090 38044 Grenoble Cedex 9 France Tel.: 00 33 (0) 457 42 86 15 [ mailto:[email protected] | e-mail: [email protected] ] FAX: 00 33 (0) 476 50 18 90 http://www.ibs.fr/ To unsubscribe from the CCP4BB list, click the following link: [ https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 | https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ] To unsubscribe from the CCP4BB list, click the following link: [ https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 | https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ] ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
