First

Y A H O O O !!!   Y II P P E E !!!

Number 1378 in the Zero Club

Zavie

I assign a Zero Club number once you reach CCR. I don't recall assigning you
one in the past, so enjoy it.

PCR values tend to fluctuate. It takes 3 consecutive results to establish a
trend. I would only worry if there as a 1 log or greater change and then ask
to be retested.

It looks like your doctor is right on top of it. I can say don't worry, but
if I had a 1 log increase I would ask to be retested.

Zavie


Zavie Miller (age 72)

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

4.4 log reduction

e-mail: [email protected]

On Thu, Feb 10, 2011 at 8:18 PM, daniel <[email protected]> wrote:

> hi all,
> i have had cml for about 3.5 years, and was originally on gleevec, but
> transferred to tasigna about a year ago due to fatigue issues with
> gleevec. i obtained ccr in the first year and since then my pcr has
> been stable, between a 2 and 3 log reduction. in the my previous
> quarterly visit my pcr had dropped to 3 log reduction for the first
> time (good news). but at my most recent visit it is back up to around
> the level it has been around for the past 2 years (bad news). my dr
> and i are concerned to see such an increase and i have a follow-up pcr
> in 5 weeks to see if it is still rising.
>
> my question is have other experienced similar increases? is it common
> to experience temporary fluctuation or does such a change usually
> indicate loss of response? obviously, i am very concerned and going to
> follow up regardless, but would be good to get a sense of others'
> experiences.
>
> thanks,
> daniel
>
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