Dear group, Hi, This is Choi from South Korea. I just wonder if anyone here has E355G mutation? One of my friends diagnosed with CML Chronic phase in 2012, started Gleevec for about 16 months. He developed mutation; E355G, so switched to Sprycel. After 1 years on Sprycel, E355G mutation disappered but He is suffering from severe pulmonary hypertension. PCR level is hovering 0.37 ~ 0.45 for 1 year. It doesn't drop under 0.1 He wants to escape from pulmonary hypertension and also hopes to drop PCR level under 0.1. To drop PCR level is increasing Sprycel but it will accelerate side effects. to decreas side effects will be stoping Sprycel but worry about E355G mutation recurring. He is just wondering if he could switch to Tasigna safely without E355G recurring. Can anyone advise?
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