Hi Choi Pulmonary Hypertension is a very serious side effect (much more than plural effusion- the most common side effect of Sprycel,), and even though I am not a Dr I know that any patient with this side effect is ordered immediately to stop Sprycel.
The patient has 2 options: the best option is switching to Tasigna, as the E355G mutation is sensitive to both 2 ed generation TKIs, Tasigna included. Another option is to give higher dose Imatinib (600 or 800 Mg), as there is some data that higher dose can overcome the resistance due to this type of mutation. I am not sure if this website accepts attached PDF files, so if you want to have some articles about this data, please email me and I will send you. My email is [email protected] Best regards and happy new year Giora CML Advocates Network From: [email protected] [mailto:[email protected]] On Behalf Of Choi Sent: Friday, January 02, 2015 1:40 PM To: [email protected] Subject: [CMLHope] E355G mutation Dear group, Hi, This is Choi from South Korea. I just wonder if anyone here has E355G mutation? One of my friends diagnosed with CML Chronic phase in 2012, started Gleevec for about 16 months. He developed mutation; E355G, so switched to Sprycel. After 1 years on Sprycel, E355G mutation disappered but He is suffering from severe pulmonary hypertension. PCR level is hovering 0.37 ~ 0.45 for 1 year. It doesn't drop under 0.1 He wants to escape from pulmonary hypertension and also hopes to drop PCR level under 0.1. To drop PCR level is increasing Sprycel but it will accelerate side effects. to decreas side effects will be stoping Sprycel but worry about E355G mutation recurring. He is just wondering if he could switch to Tasigna safely without E355G recurring. Can anyone advise? -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.
