Hi This good article is 3 years old from ASH 2011. The new data about stopping treatment presented last month at ASH 2014, is not included there and some of the data in the article is outdates. (for example there is already trials on stopping after 2 ed generation TKIs.
If you want to read summaries of the latest data from ASH 2014, including stopping treatment, data on Ponatinib and more, you can go to our website and read our summaries from ASH. www.cmladvocates.net there are already 3 reports published and the last one on CML in children will be published soon. Happy new year to all Giora From: [email protected] [mailto:[email protected]] Sent: Sunday, January 04, 2015 1:59 PM To: [email protected] Subject: [CMLHope] Good article on stopping tki http://asheducationbook.hematologylibrary.org/content/2011/1/136.full Sent from my iPhone On Jan 3, 2015, at 11:28 AM, "'Icandoallttc' via CMLHope" <[email protected]> wrote: Hi all >From my experience gleevec quit working for me after 5 years--it probably was >a mutation but was never told. I started on full dose tasigna but it quit >working after only a few months. I then was placed on 150 Mgs sprycel. It worked great with no PE. However some people do get PE from sprycel. I am now on 100 Mgs daily sprycel. Work with the doctor and keep good checks on the blood. Blessings Jeanie🐟 Sent from my iPhone On Jan 2, 2015, at 6:39 AM, Choi <[email protected]> wrote: Dear group, Hi, This is Choi from South Korea. I just wonder if anyone here has E355G mutation? One of my friends diagnosed with CML Chronic phase in 2012, started Gleevec for about 16 months. He developed mutation; E355G, so switched to Sprycel. After 1 years on Sprycel, E355G mutation disappered but He is suffering from severe pulmonary hypertension. PCR level is hovering 0.37 ~ 0.45 for 1 year. It doesn't drop under 0.1 He wants to escape from pulmonary hypertension and also hopes to drop PCR level under 0.1. To drop PCR level is increasing Sprycel but it will accelerate side effects. to decreas side effects will be stoping Sprycel but worry about E355G mutation recurring. He is just wondering if he could switch to Tasigna safely without E355G recurring. Can anyone advise? -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.
