David,
The Bible tells us that God will not give us more than we can handle, but I
think you are coming close. So sorry you have to deal with two blood problems
at the same time. I see you live in Northern Michigan. Have you considered
seeing Dr Talpaz in Ann Arbor at the University of Michigan Cancer Center? My
husband comes all the way from Southern Illinois to see him. He is very
knowledgable in CML and I am sure he treats other leukemia types as well. He
was instrumental in the formation of Gleevec and Sprycel and several other
TKIs. We recommend him highly. But I am sure you are getting good care at
Mayo. Please stay in touch and let us know how you are progressing. You are
in my prayers. God bless and keep you.
Joyce in IL
On Apr 3, 2015, at 9:12 AM, גיורא wrote:
> Dear David
> You are a special brave person and i wish you all the best and great success
> on your dual fight.
> You are the only person i have heard of that is on both Ibrutinib and
> Imatinib at the same time
> My best regards
> Giora
>
> נשלח מה-iPhone שלי
>
> ב-3 באפר׳ 2015, בשעה 16:51, David Bradley <[email protected]> כתב/ה:
>
>> Thanks Beth!
>>
>> Time for another update. Based on my PCR that was negative for CML in
>> December, and my looming CLL, I was taken off Gleevec, and started Imbruvica
>> for my CLL, with the hope that the CML would remain dormant. There have
>> been two slip-ups since then. The Imbruvica triggered a heart problem, an
>> atrial fibrillation in February. At the end of a week in hos[pital, I was
>> given one of those treatments with the electric paddles and fortunately
>> immediately went back into a good rhythm. Arriving home, I started a
>> recovery process in which I am still weaker than I was, but a bit better
>> every day.
>>
>> Then it was time for a new PCR. My old nemesis, the Philadelphia
>> chromosome, was back (that was quick!). So now I am back on Gleevec. My
>> Imbruvica has to be on a 1/3 basis, since both drugs are Bruton's Tyrosine
>> Kinase inhibitors, and both use the CYP3A4 pathway.
>>
>> It has only been since December that I was off Gleevec, but my heartburn
>> reminds me of the main downside I had from it. Still, I have faith it can
>> keep the CML at bay.
>>
>> Anyway, as I said, I'm better every day, and besides, spring has finally
>> come to northern Michigan.
>>
>> David
>>
>>
>>
>> On Wednesday, December 17, 2014 at 12:35:08 PM UTC-5, Beth wrote:
>> Good luck to you David. It sounds so hard..glad you reconnected
>> here....after being diagnosed and doing well for 12 years....hope the meds
>> support you well with the CLL. happiest of holidays to you and yours. Beth.
>>
>>
>>
>> -----Original Message-----
>> From: Richard H <[email protected]>
>> To: cmlhope <[email protected]>
>> Cc: icandoallttc <[email protected]>
>> Sent: Sun, Dec 14, 2014 12:33 am
>> Subject: Re: [CMLHope] Dual Diagnosis: CLL/ CML
>>
>> I could not meet the requirements. I have too many other health issues that
>> would interfere with the results they were looking for. When I was first
>> diagnosed they ruled me out of a BMT for the same reasons.
>>
>> Richard H.
>>
>> On Saturday, December 13, 2014 2:07:12 PM UTC-6, Icandoallttc wrote:
>> Hi David
>> So good to hear from you.
>> Marty sent us a site not long ago about a study for going off Gleevec.
>> There are certain things you must meet to be in the study.
>> Glad you are negative.
>> Blessings
>> Jeanie
>>
>> Sent from my iPhone
>>
>> On Dec 13, 2014, at 12:00 PM, [email protected] wrote:
>>
>>> Hi,
>>>
>>> Hello everyone.
>>>
>>> I have posted here long ago, when I was first diagnosed with CML, in 2003.
>>> At the time, I started on Gleevec, and immediately had a Complete
>>> Remission, via FISH. Unfortunately, I also showed signs of CLL, which was
>>> confirmed. The CLL has been on "watchful waiting" until now.
>>>
>>> Recently my counts got very negative, due to the CLL, and I went to Mayo
>>> and found I have a 17p deletion, which is quite negative. For the CLL, I
>>> will go on Ibrutinib, a targeted therapy. Since Ibrutinib is a tyrosine
>>> kinase inhibitor, I will need to stop Gleevec, at least for a while.
>>>
>>> I kind of wish my onc had been doing PCR's for a while, but at Mayo they
>>> did one and found my CML was undetectable.
>>>
>>> Can anyone point me to any studies about stopping Gleevec after long
>>> periods (in my case around 10 years) of Complete (or molecular) remission?
>>>
>>> The current plan is to check with regular PCR's for a reemergence of the
>>> BCR-ABL.
>>>
>>> Best wishes to all...
>>>
>>> David
>>>
>>>
>>> --
>>> --
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>>
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